Minirin Tablets

দেশ: অস্ট্রেলিয়া

ভাষা: ইংরেজি

সূত্র: Department of Health (Therapeutic Goods Administration)

সক্রিয় উপাদান:

Desmopressin acetate

থেকে পাওয়া:

Ferring Pharmaceuticals Pty Ltd

শ্রেণী:

Medicine Registered

তথ্য লিফলেট

MINIRIN
®
 TABLETS

_Desmopressin acetate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Minirin Tablets.
It does not contain all the available
information. It does not replace of
talking to your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Minirin
Tablets against the benefits they
expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT MINIRIN IS USED
FOR
The active ingredient, desmopressin
acetate in Minirin Tablets is a
synthetic version of a naturally
occurring substance produced in the
brain called vasopressin.
It has a number of different actions
on the body including an action on
the kidney to reduce the amount of
urine produced. This means that
Minirin Tablets can be used for
several different conditions
including:
•
primary nocturnal enuresis
(bedwetting) in patients over 6
years of age who have a normal
ability to concentrate urine and
who have not responded to
treatment with an enuresis alarm
or in whom an enuresis alarm is
contraindicated or inappropriate
•
cranial diabetes insipidus (large
amounts of urine being produced
day and night and constant thirst).
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another reason.
This medicine is not addictive.
It is available only with a doctor's
prescription.
This medicine is not expected to
affect your ability to drive a car or
operate machinery.
BEFORE YOU TAKE
MINIRIN
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE MINIRIN TABLETS IF YOU
HAVE AN ALLERGY TO:
•
any medicine containing
desmopressin or any of the
ingredients listed at the end of
this leaflet.
Some of the symptoms of an allergic
reaction may include:
•
shortness of breath, wheezing or
difficulty breathing
•
swelling of the face, lips, tongue
or

পণ্য বৈশিষ্ট্য

PRODUCT INFORMATION 

1                                          
                               #1735-v21A 
_MINIRIN_
_®_
_ TABLETS _

NAME OF THE MEDICINE: 
Desmopressin Acetate 
Synonyms of desmopressin: 
DDAVP 
1-desamino-8-D-Arginine vasopressin. 
Desamino-cys-1-D-Arginine-8 vasopressin. 

 SCH
2
CH
2
CO-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH
2

 CAS No. 62357-86-2 (trihydrate) 

DESCRIPTION: 
The active substance, desmopressin, (present as the
hydrated acetate with variable amounts of acetic acid and 
water) is a synthetic structural analogue of the natural pituitary hormone arginine vasopressin.
 The difference 
lies in the desamination of cysteine and substitution
of L-arginine by D-arginine. Minirin Tablets contain 
desmopressin, lactose, potato starch, povidone and
magnesium stearate. 

PHARMACOLOGY: 
Actions: Pharmacotherapeutic group: vasopressin and analogues. 
Compared to vasopressin, desmopressin
has a considerably longer duration of action and
a complete lack of 
pressor effect in the dosages clinically used. 
Pharmacokinetics: The absolute bioavailability of orally administered Minirin 200µg tablets is 
approximately 0.08% (range 0.029 - 0.115%). Mean
maximum plasma concentration is reached within 2 
hours.  The distribution volume is 0.2 – 0.37 L/kg.
Desmopressin does not cross the blood-brain barrier.  
The oral terminal half-life varies between 2.0 and 3.21 hours.
The bioequivalence of the 200 and 400µg 
Minirin Tablets has not been established. Desmopressin
exhibits a moderate to high variability in 
bioavailability, both within and between
subjects. Concomitant intake of food decreases the rate
and extent 
of absorption of Minirin 200µg tablets, administered at a dose
of 400µg, by >40%. In vitro in human liver 
microsome preparations, it has been shown that no
significant�