Minirin Nasal Spray

দেশ: অস্ট্রেলিয়া

ভাষা: ইংরেজি

সূত্র: Department of Health (Therapeutic Goods Administration)

সক্রিয় উপাদান:

Desmopressin acetate

থেকে পাওয়া:

Ferring Pharmaceuticals Pty Ltd

শ্রেণী:

Medicine Registered

তথ্য লিফলেট

MINIRIN
®
 NASAL SPRAY

_Desmopressin acetate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Minirin Spray.
It does not contain all the available
information. It does not replace of
talking to your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Minirin Spray
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT MINIRIN IS USED
FOR
The active ingredient, desmopressin
acetate in Minirin Spray is a
synthetic version of a naturally
occurring substance produced in the
brain called vasopressin.
It has a number of different actions
on the body including an action on
the kidney to reduce the amount of
urine produced. This means that
Minirin Spray can be used for several
different conditions including:
•
primary nocturnal enuresis
(bedwetting) in patients over 6
years of age, who have a normal
ability to concentrate urine and
who have not responded to
treatment with an enuresis alarm
or in patients in whom an
enuresis alarm is contraindicated
or inappropriate
•
cranial diabetes insipidus (large
amounts of urine being produced
day and night and constant thirst)
•
as a diagnostic test to establish if
the kidneys have the ability to
concentrate urine.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another reason.
This medicine is not addictive.
It is available only with a doctor's
prescription.
This medicine is not expected to
affect your ability to drive a car or
operate machinery.
BEFORE YOU TAKE
MINIRIN
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE MINIRIN SPRAY IF YOU
HAVE AN ALLERGY TO:
•
any medicine containing
desmopressin or any of the
ingredients listed at the end of
this leaflet.
Some of the symptoms of an allergic
reaction may include:
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পণ্য বৈশিষ্ট্য

PRODUCT INFORMATION 

#152-v14A 

_ _
_MINIRIN_
_®_
_ NASAL SPRAY _
NAME OF THE MEDICINE: 
Desmopressin Acetate 
Synonyms: 
DDAVP 
1-desamino-8-D-Arginine vasopressin. 
Desamino-cys-1-D-Arginine-8 vasopressin. 
CAS No. 62357-86-2 (trihydrate) 

DESCRIPTION: 
The active substance is a synthetic structural analogue of the natural hormone arginine vasopressin.  Early treatment of central 
diabetes insipidus used a more or less purified extract from bovine or porcine posterior pituitaries.  These caused unpleasant 
complications of use.  When vasopressin became known, two forms were found - Arginine
Vasopressin (found in humans) and 
lysine vasopressin (found in pig pituitaries). 
Two chemical changes have been made to the natural hormone: 
a.  desamination of the N-terminal of  cysteine-1 
b.  substitution of 8-D-arginine for 8-L-arginine 
SCH
2
CH
2
CO-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH
2

Minirin Nasal Spray contains desmopressin
acetate, sodium chloride, citric acid
monohydrate, sodium phosphate-dibasic 
dihydrate, benzalkonium chloride solution 50% as preservative and
purified water. 

PHARMACOLOGY: 
According to results from antidiuretic and pressor tests in
rats these changes increase antidiuretic activity three to five
fold while 
pressor activity is reduced to
0.1% of that of antidiuretic hormone. 
Pharmacokinetics 
a.  Absorption:  Using
i.v. or i.m. doses, 100% is available.  Used
intranasally, it is estimated
that 10% is available.  Thus i.v. or 
i.m. doses are one tenth that of the intranasal route.  The extent of absorption is similar for the spray and the rhinyle with a 
trend towards higher absorption associated with the spray. 
Mean C
max
 and AUC values are approximately 40% highe