Country: অস্ট্রেলিয়া
ভাষা: ইংরেজি
সূত্র: Department of Health (Therapeutic Goods Administration)
metformin hydrochloride, Quantity: 500 mg
Arrotex Pharmaceuticals Pty Ltd
Metformin hydrochloride
Tablet, modified release
Excipient Ingredients: carmellose sodium; ethanol; magnesium stearate; microcrystalline cellulose; hypromellose; colloidal anhydrous silica
Oral
120 tablets, 90 tablets per pack.
(S4) Prescription Only Medicine
Treatment of Type 2 diabetes mellitus in adults, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control. METFORMIN ARW XR may be used as monotherapy or in combination with other oral antidiabetic agents, or with insulin.
Visual Identification: White, capsule shaped tablet, debossed with XR5 on one side and 'Arrow' logo on the other side.; Container Type: Blister Pack; Container Material: PVC/PE/PVDC/Al; Container Life Time: 4 Years; Container Temperature: Store below 25 degrees Celsius
Registered
2008-09-12
METEX XR- Consumer Medicine Information Page 1 of 5 Metex XR metformin hydrochloride CONSUMER MEDICINE INFORMATION (CMI) WHAT IS IN THIS LEAFLET This leaflet answers some common questions about METEX XR. It does not contain all of the available information. It does not take the place of talking to your doctor, pharmacist or diabetes educator. All medicines have benefits and risks. Your doctor has weighed the risks of you taking METEX XR against the benefits they expect it will have for you. TALK TO YOUR DOCTOR, PHARMACIST OR DIABETES EDUCATOR IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may need to read it again. WHAT METEX XR IS USED FOR The medicine is used to control blood glucose in patients with Type 2 diabetes mellitus, especially in those who are overweight. It is used when diet and exercise are not enough to control your blood glucose levels. It can be used alone, or in combination with other medicines for treating diabetes. Type 2 diabetes mellitus is also called non-insulin dependent diabetes mellitus (NIDDM) or maturity onset diabetes. Insulin is a hormone that enables body tissues to take up glucose from the blood and use it for energy or fat storage for future use. People with type 2 diabetes are unable to make enough insulin or their body does not respond properly to the insulin it does make. This causes a build-up of glucose in the blood (hyperglycaemia), which can lead to serious medical problems. Long term hyperglycaemia can lead to heart disease, blindness, kidney damage, poor blood circulation and gangrene. Signs of hyperglycaemia include: • tiredness or lack of energy • headache • thirst • passing large amounts of urine • blurred vision. METEX XR is available only with a doctor's prescription. There is no evidence that the medicine is addictive. How METEX XR w orks METEX XR belongs to a group of medicines called biguanides. It lowers high blood glucose levels by: • improving your body’s sensitivity to insulin and restoring the way সম্পূর্ণ নথি পড়ুন
METAX XR- Product Information Page 1 of 10 Metex XR PRODUCT INFORMATION Life threatening lactic acidosis can occur due to accumulation of metformin. The main risk factor is renal impairment; other risk factors include old age associated with reduced renal function. NAME OF THE MEDICINE Metformin hydrochloride. The chemical name for metformin hydrochloride is 1,1 dimethyl biguanide hydrochloride. Its structural formula is: C 4 H 11 N 5 .HCl Molecular weight: 165.6 Cas No.: 1115-70-4 DESCRIPTION Metformin hydrochloride is a white, crystalline powder which is freely soluble in water, sparingly soluble in alcohol, practically insoluble in acetone and methylene chloride. Metformin is a strong base with a pKa greater than 12. At pH < 12, which is always the case in the body, metformin is very hydrophilic: the octanol/water partition coefficient is 0.05. The melting point of metformin hydrochloride is 224°C. Metformin hydrochloride is a very stable molecule. Metex XR are extended release tablets that contain 500 mg of metformin hydrochloride. The tablets also contain the following excipients: carmellose sodium, hypromellose, colloidal anhydrous silica, microcrystalline cellulose and magnesium stearate. The tablets are gluten free. PHARMACOLOGY Metformin is a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycaemia. Metformin may act via three mechanisms. 1) Reduction of hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis. 2) In muscle, by increasing insulin sensitivity, improving peripheral glucose uptake and utilisation. 3) Delay of intestinal glucose absorption. Metformin stimulates intracellular glycogen synthesis by acting on glycogen synthase. Metformin increases the transport capacity of all types of membrane glucose transporters (GLUT). In humans, independently of its action on glycaemia, metformin has favourable effects on lipid metabolism. This has been shown at th সম্পূর্ণ নথি পড়ুন