দেশ: মাল্যাশিয়া
ভাষা: ইংরেজি
সূত্র: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
LEVOCETIRIZINE DIHYDROCHLORIDE
CAMBER LABORATORIES SDN. BHD.
LEVOCETIRIZINE DIHYDROCHLORIDE
30Tablet Tablets
"HETERO DRUGS LIMITED"
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ LAZINE 5MG TABLETS Levocetirizine dihydrochloride (5mg) 1 WHAT IS IN THIS LEAFLET 1. What LAZINE _ _ is used for 2. How LAZINE _ _ works 3. Before you use LAZINE 4. How to use LAZINE 5. While you are using it 6. Side effects 7. Storage and Disposal of LAZINE 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT LAZINE_ _IS USED FOR LAZINE is used to treat the symptoms of: • Allergic rhinitis (inflammation of the mucous membrane inside the nose) including persistent allergic rhinitis. • Long term hives of unknown cause. HOW LAZINE WORKS LAZINE contains the active ingredient levocetirizine dihydrochloride. LAZINE is an antiallergic medication. It works by blocking a certain natural substance (histamine) that your body makes during allergic reaction. BEFORE YOU USE LAZINE _-When you must not use it _ Do not take LAZINE if you have: • Allergy (hypersensitivity) to the active ingredient levocetirizine dihydrochloride, cetirizine, piperazine or any of the ingredients listed contained in the product. • Severe kidney impairment at less than 10 ml/min creatinine clearance. The use of LAZINE is not recommended for infants and children under 6 years. _Pregnancy and breastfeeding _ Ask your doctor or pharmacist for advice before taking any medicine. Tell your doctor if you are pregnant, trying to get pregnant or breastfeeding. _-Before you start to use it _ Tell your doctor if you have been told by your doctor that you have an intolerance to some sugars. This tablet contains lactose. _-Taking other medicines _ Tell your doctor or pharmacist if you are taking theophylline (used to treat asthma) or any other medicines including those that you get without a prescription. HOW TO USE LAZINE _-How much to use _ Always take LAZINE exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. The usual daily dose for: • Adults and children aged 6 years old and above: 5mg (1 film-coated t সম্পূর্ণ নথি পড়ুন
LAZINE 5 MG TABLET (LEVOCETIRIZINE DIHYDROCHLORIDE TABLET 5MG) Font: Time News Roman, size 7 DESCRIPTION AND COMPOSITION : White film coated, scored, round shaped, standard concave tablets, debossed with ‘161’ on one side and ‘H’ on the other side. Each film coated tablet contains: Levocetirizine Dihydrochloride 5mg. PHARMACODYNAMIC PROPERTIES: Levocetirizine, the (R) enantiomer of cetirizine, is a potent and selective antagonist of peripheral H1-receptors. Binding studies revealed that levocetirizine has high affinity for human H1-receptors (Ki= 3.2 nmol/l). Levocetirizine has an affinity 2-fold higher than that of cetirizine (Ki = 6.3 nmol/l). Levocetirizine dissociates from H1-receptors with a half-life of 115 ± 38 min. After single administration, levocetirizine shows a receptor occupancy of 90% at 4 hours and 57% at 24 hours. Pharmacodynamic studies in healthy volunteers demonstrate that, at half the dose, levocetirizine has comparable activity to cetirizine, both in the skin and in the nose. The pharmacodynamic activity of levocetirizine has been studied in randomised, controlled trials: In a study comparing the effects of levocetirizine 5mg, desloratadine 5mg, and placebo on histamine-induced wheal and flare, levocetirizine treatment resulted in significantly decreased wheal and flare formation which was highest in the first 12 hours and lasted for 24 hours, (p<0.001) compared with placebo and desloratadine. The onset of action of levocetirizine 5 mg in controlling pollen-induced symptoms has been observed at 1 hour post drug intake in placebo-controlled trials in the model of the allergen challenge chamber. In vitro studies (Boyden chambers and cell layers techniques) show that levocetirizine inhibits eotaxin-induced eosinophil transendothelial migration through both dermal and lung cells. A pharmacodynamic experimental study in vivo (skin chamber technique) showed three main inhibitory effects of levocetirizine 5 mg in the first 6 hours of pollen- induced reaction, compared with placebo in 14 ad সম্পূর্ণ নথি পড়ুন