L-METHYL-MC-NAC - levomefolate calcium, methylcobalamin, and acetylcysteine tablet, coated

দেশ: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

LEVOMEFOLATE CALCIUM (UNII: A9R10K3F2F) (LEVOMEFOLIC ACID - UNII:8S95DH25XC), METHYLCOBALAMIN (UNII: BR1SN1JS2W) (METHYLCOBALAMIN - UNII:BR1SN1JS2W), ACETYLCYSTEINE (UNII: WYQ7N0BPYC) (ACETYLCYSTEINE - UNII:WYQ7N0BPYC)

থেকে পাওয়া:

AvKARE, Inc.

INN (আন্তর্জাতিক নাম):

LEVOMEFOLATE CALCIUM

রচনা:

LEVOMEFOLATE CALCIUM 6 mg

প্রশাসন রুট:

ORAL

থেরাপিউটিক ইঙ্গিত:

L-Methyl-MC-NAC Tablets is indicated for the distinct nutritional requirements of individuals under a physician's treatment for early memory loss 25 with particular emphasis for those individuals diagnosed with or at risk for neurovascular oxidative stress 14,16,18 and/or hyperhomocysteinemia 18 ; mild to moderate cognitive impairment with or without vitamin B12 deficiency 9,13,19 , vascular dementia 12,13,21 or Alzheimer's disease 12,13,16,21 . L-Methyl-MC-NAC Tablets should always be used under medical supervision. There have been rare reports of hypersensitivity (allergic-like reactions) to L-Methyl-MC-NAC Tablets. Therefore, a known hypersensitivity to any components in the product is a contraindication to its use for any indication.

পণ্য সারাংশ:

Available as an oval coated blue colored caplet. Debossed with "V361" on one side and blank on the other. Supplied in bottles of 90 caplets  (NDC  42291-362-90). Use under medical/physician supervision Store at controlled room temperature 15°C to 30°C (59°F to 86°F) (See USP). Protect from light and moisture.

অনুমোদন অবস্থা:

MEDICAL FOOD

পণ্য বৈশিষ্ট্য

L-METHYL-MC-NAC - LEVOMEFOLATE CALCIUM, METHYLCOBALAMIN, AND
ACETYLCYSTEINE TABLET,
COATED
AVKARE, INC.
----------
L-METHYL-MC-NAC TABLETS
DESCRIPTION
L-METHYL-MC-NAC TABLETS is an orally administered prescription medical
food for the dietary
management of certain metabolic processes identified with early memory
loss.
Each oval coated blue colored caplet contains:
_Dietary Ingredients:_
L-methylfolate Calcium
6 mg
Methylcobalamin
2 mg
N-Acetylcysteine
600
mg
INGREDIENTS
N-acetylcysteine Microcrystalline Cellulose, Opadry II Blue 07F90856
(Hypromellose, Talc, Titanium
Dioxide, Polyethylene Glycol, FD&C Blue #2-Aluminum Lake, Saccharin
Sodium), Magnesium
Stearate (Vegetable Source), L-methylfolate Calcium, Methylcobalamin,
and Carnauba Wax.
L-METHYL-MC-NAC Tablets do not contain sugar, lactose, yeast or
gluten.
PHARMACOLOGY
_L-methylfolate or 6(S)-5-methyltetrahydrofolate [6(S)-5-MTHF]_, is
the primary biologically active isomer
of folate
and the form of folate in circulation
. It is also the form which is transported across
membranes into peripheral tissues
, particularly across the blood brain barrier
. In the cell, 6(S)-5-
MTHF is used in the methylation of homocysteine to form methionine and
tetrahydrofolate (THF)
.
THF is the immediate acceptor of one carbon units for the synthesis of
thymidine-DNA, purines (RNA
and DNA) and methionine
. Folic acid, the synthetic form of folate, must undergo enzymatic
reduction
by methylenetetrahydrofolate reductase (MTHFR) to become biologically
active
. Certain genetic
mutations of MTHFR result in a cell's inability to convert folic acid
to 6(S)-5-MTHF
.
_Methylcobalamin (Methyl-B_
_)_ is one of two forms of biologically active vitamin B
. Methyl-B
is the
principal form of circulating vitamin B
, hence the form which is transported into peripheral tissue.
Methyl-B
is absorbed by a specific intestinal mechanism which uses intrinsic
factor and by a diffusion
process in which approximately 1% of the ingested dose is absorbed.
Cyanocobalamin and
hydroxycobalamin are forms of the