FLU-NIX- flunixin meglumine injection, solution

দেশ: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

FLUNIXIN MEGLUMINE (UNII: 8Y3JK0JW3U) (FLUNIXIN - UNII:356IB1O400), PHENOL (UNII: 339NCG44TV) (PHENOL - UNII:339NCG44TV)

থেকে পাওয়া:

Agri Laboratories, Ltd

INN (আন্তর্জাতিক নাম):

FLUNIXIN MEGLUMINE

রচনা:

FLUNIXIN MEGLUMINE 50 mg in 1 mL

প্রশাসন রুট:

INTRAMUSCULAR

প্রেসক্রিপশন টাইপ:

PRESCRIPTION

থেরাপিউটিক ইঙ্গিত:

Horse :  Flu-Nix is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse.  It is also recommended for the alleviation of visceral pain associated with colic in the horse. Cattle :  Flu-Nix is indicated for the control of pyrexia associated with bovine respiratory disease, endotoxemia and acute bovine mastitis.   Flu-Nix is also indicated for the control of inflammation in endotoxemia. Horse : There are no known contraindications to this drug when used as directed.  Intra-arterial injection should be avoided.  Horses inadvertently injected intra-arterial can show adverse reactions.  Signs can be ataxia, incoordination, hyperventilation, hysteria, and muscle weakness.  Signs are transient and disappear without antidotal medication within a few minutes.  Do not use in horses showing hypersensitivity to flunixin meglumine. Cattle :  There are no known contraindications to this drug in cattle when used as directed.  Do not use in animals showing hypersensi

পণ্য সারাংশ:

Flu-Nix, 50 mg/mL, is available in 100 mL and 250 mL multi-dose vials.

অনুমোদন অবস্থা:

Abbreviated New Animal Drug Application

পণ্য বৈশিষ্ট্য

FLU-NIX - FLUNIXIN MEGLUMINE INJECTION, SOLUTION
AGRI LABORATORIES, LTD
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FLU-NIX
(FLUNIXIN MEGLUMINE)
INJECTABLE SOLUTION 50 MG/ML
ANADA 200-061, APPROVED BY FDA
VETERINARY
For Intravenous or Intramuscular Use in Horses and for Intravenous Use
in Beef and Dairy Cattle. Not
for Use in Dry Dairy Cows and Veal Calves.
Read accompanying directions for use.
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed veterinarian.
DES CRIPTION
Each milliliter of Flu-Nix contains flunixin meglumine equivalent to
50 mg flunixin, 0.1 mg edetate
disodium, 2.5 mg sodium formaldehyde sulfoxylate, 4.0 mg
diethanolamine, 207.2 mg propylene glycol,
5.0 mg phenol as preservative, hydrochloric acid, water for injection
q.s.
PHARMACOLOGY
Flunixin meglumine is a potent, non-narcotic, non-steroidal, analgesic
agent with anti-inflammatory and
anti-pyretic activity. It is significantly more potent than
pentazocine, meperidine and codeine as an
analgesic in the rat yeast paw test.
HORSE: Flunixin is four times as potent on a mg/per mg basis as
phenylbutazone as measured by the
reduction of lameness and swelling in the horse. Plasma half-life in
horse serum is 1.6 hours following
a single dose of 1.1 mg/kg. Measurable amounts are detectable in horse
plasma at 8 hours post injection.
CATTLE: Flunixin meglumine is a weak acid (pKa=5.82) which exhibits a
high degree of plasma protein
binding (approximately 99%).
However, free (unbound) drug appears to readily partition into body
tissues (V predictions range from 297 to 782 mL/kg.
Total body water is approximately equal to
570 ml/kg).
In cattle, elimination occurs primarily through biliary elimination
occurs primarily through
biliary excretion.
This may, at least in part, explain the presence of multiple peaks in
the blood
concentration/time profile following IV administration.
In healthy cattle, total body clearance has been
reported to range from 90 to 151 mL/kg/hr.
These studies also report a large discrepancy between
the volume of distribution at a steady