Country: নিউ জিলণ্ড
ভাষা: ইংরেজি
সূত্র: Medsafe (Medicines Safety Authority)
Disodium edetate 150 mg/mL (Added as disodium edetate hydrous 166mg)
Centre for Advanced Medicine
Disodium edetate 150 mg/mL (Added as disodium edetate hydrous 166mg)
150 mg/mL
Solution for injection
Active: Disodium edetate 150 mg/mL (Added as disodium edetate hydrous 166mg) Excipient: Hydrochloric acid Sodium hydroxide Water for injection
Ampoule, glass, Type 1 (not marketed), 20 mL
Prescription
Prescription
Akzo Nobel Chemicals bv
Package - Contents - Shelf Life: Ampoule, glass, Type 1 - 20 mL - 36 months from date of manufacture stored at or below 25°C - Vial, glass, crimp seal - 100 mL - 36 months from date of manufacture stored at or below 25°C - Vial, glass, screw cap - 100 mL - 36 months from date of manufacture stored at or below 25°C
1984-04-18
NEW ZEALAND DATASHEET NAME OF MEDICINE EDETATE DISODIUM INJECTION, USP PRESENTATION Edetate Disodium Injection, USP is a sterile, non-pyrogenic, concentrated solution of edetate disodium in water for injection, which, as a result of pH adjustment with sodium hydroxide, contains varying amounts of disodium and trisodium salts. Each ml contains: Edetate Disodium anhydrous 150mg, in Water for Injection q.s. pH is adjusted with Sodium Hydroxide and if necessary Hydrochloric Acid. Approximate pH is 7 (range 6.5 – 7. 5 ). USES ACTIONS Edetate disodium is classified as a clinical chelating agent for emergency lowering of serum calcium in hypercalcemia. Edetate disodium, USP is chemically designated disodium (ethylene-dinitrilo) tetra-acetate dihydrate, a white crystalline powder soluble in water. It is also described as the disodium salt of ethylenediamine-tetra-acetic acid (EDTA). Edetate disodium injection forms chelates with the cations of calcium and many divalent and trivalent metals. Because of its affinity for calcium, edetate disodium will produce a lowering of the serum calcium level during intravenous infusion. Slow infusion over a protracted period may cause mobilization of extracirculatory calcium stores. Edetate disodium exerts a negative inotropic effect upon the heart. PHARMACOKINETICS After intravenous administration, the chelate formed is excreted in the urine with 50% appearing in 1 hour and over 95% in 24 hours. Edetate disodium likewise forms chelates with other polyvalent metals and produces increases in urinary excretion of magnesium, zinc and other trace elements. It does not form a chelate with potassium but may reduce the serum level and increase urinary loss of potassium. INDICATIONS Edetate Disodium injection is indicated in selected patients for the emergency treatment of hypercalcemia and for the control of ventricular arrhythmias associated with digitalis toxicity. DOSAGE AND ADMINISTRATION Edetate Disodium injection is administered by intravenous infusion only after dilution. The solutio সম্পূর্ণ নথি পড়ুন