DOXYCYCLINE MONOHYDRATE tablet

দেশ: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

DOXYCYCLINE (UNII: N12000U13O) (DOXYCYCLINE ANHYDROUS - UNII:334895S862)

থেকে পাওয়া:

American Health Packaging

INN (আন্তর্জাতিক নাম):

DOXYCYCLINE

রচনা:

DOXYCYCLINE ANHYDROUS 100 mg

প্রেসক্রিপশন টাইপ:

PRESCRIPTION DRUG

অনুমোদন অবস্থা:

Abbreviated New Drug Application

পণ্য বৈশিষ্ট্য

DOXYCYCLINE MONOHYDRATE- DOXYCYCLINE TABLET
AMERICAN HEALTH PACKAGING
----------
DOXYCYCLINE TABLETS, USP
8278521/0815OS
RX ONLY
DOXYCYCLINE TABLETS, USP
RX ONLY
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of doxycycline
tablets and other antibacterial drugs, doxycycline tablets should be
used only to treat or prevent
infections that are proven or strongly suspected to be caused by
bacteria.
DESCRIPTION
Doxycycline, USP is a broad-spectrum antibiotic synthetically derived
from oxytetracycline.
Doxycycline 150 mg, 100 mg, 75 mg and 50 mg tablets contain
doxycycline monohydrate equivalent to
150 mg, 100 mg, 75 mg or 50 mg of doxycycline for oral administration.
Inactive ingredients include
colloidal silicon dioxide, FD&C yellow #6, magnesium stearate,
microcrystalline cellulose, sodium
starch glycolate, and titanium dioxide. In addition, Doxycycline 100
mg and 50 mg tablets contain
hypromellose 3cP, hypromellose 6cP, D&C yellow #10 lake, polyethylene
glycol 400, polysorbate
80; Doxycycline 75 mg and 150 mg tablets contain hypromellose 15cP,
lactose monohydrate, yellow
iron oxide and triethyl citrate. Its molecular weight is 462.46. The
chemical designation of the light-
yellow crystalline powder is alpha-6-deoxy-5-oxytetracycline.
Structural formula:
C
H
N
O
•H
O
Doxycycline has a high degree of lipid solubility and a low affinity
for calcium binding. It is highly
stable in normal human serum. Doxycycline will not degrade into an
epianhydro form.
22
24
2
8
2
CLINICAL PHARMACOLOGY
Tetracyclines are readily absorbed and are bound to plasma proteins in
varying degrees. They are
concentrated by the liver in the bile and excreted in the urine and
feces at high concentrations in a
biologically active form. Doxycycline is virtually completely absorbed
after oral administration.
Following a 200 mg dose of doxycycline monohydrate, 24 normal adult
volunteers averaged the
following serum concentration values:
Time (hr):
0.5
1.0
1.5
2.0
3.0
4.0
8.0
12.0
24.0
48.0
72.0
Conc (mcg/mL):
1.