DOXYCYCLINE hyclate tablet coated

দেশ: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

DOXYCYCLINE HYCLATE (UNII: 19XTS3T51U) (DOXYCYCLINE ANHYDROUS - UNII:334895S862)

থেকে পাওয়া:

Medsource Pharmaceuticals

INN (আন্তর্জাতিক নাম):

DOXYCYCLINE HYCLATE

রচনা:

DOXYCYCLINE ANHYDROUS 100 mg

প্রেসক্রিপশন টাইপ:

PRESCRIPTION DRUG

অনুমোদন অবস্থা:

Abbreviated New Drug Application

পণ্য বৈশিষ্ট্য

DOXYCYCLINE- DOXYCYCLINE HYCLATE TABLET, COATED
MEDSOURCE PHARMACEUTICALS
----------
DOXYCYCLINE HYCLATE
TABLETS, USP
REV. 11/14
RX ONLY
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of doxycycline
hyclate tablets and other antibacterial drugs, doxycycline hyclate
tablets should be used only to treat or
prevent infections that are proven or strongly suspected to be caused
by bacteria.
DESCRIPTION
Doxycycline hyclate is an antibacterial drug synthetically derived
from oxytetracycline. The structural
formula of doxycycline monohydrate is
with a molecular formula of C
H
N
O
•H
O and a molecular weight of 462.46. The chemical
designation for doxycycline is
4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-
pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrate.
The molecular formula
for doxycycline hydrochloride hemiethanolate hemihydrate is (C
H
N
O
•HCl)
•C
H
O•H
O
and the molecular weight is 1025.89. Doxycycline is a light yellow
crystalline powder. Doxycycline
hyclate is soluble in water, while doxycycline monohydrate is very
slightly soluble in water.
Doxycycline has a high degree of lipoid solubility and a low affinity
for calcium binding. It is highly
stable in normal human serum. Doxycycline will not degrade into an
epianhydro form.
Each tablet for oral administration contains doxycycline hyclate
equivalent to 100 mg of doxycycline
(anhydrous). Inactive ingredients are: Colloidal Silicon Dioxide, Corn
Starch, Croscarmellose Sodium,
Docusate Sodium, Sodium Benzoate, Magnesium Stearate, and
Microcrystalline Cellulose. Film Coating
and Polishing contains: FD&C Blue No. 2, FD&C Yellow No. 6,
Hydroxypropyl Methylcellulose,
Polyethylene Glycol, and Titanium Dioxide.
CLINICAL PHARMACOLOGY
Tetracyclines are readily absorbed and are bound to plasma proteins in
varying degree. They are
concentrated by the liver in the bile, and excreted in the urine and
feces at high concentrations and in a
biologically active form. Doxycycline is virtually compl