BENAZEPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE tablet, film coated

Country: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

BENAZEPRIL HYDROCHLORIDE (UNII: N1SN99T69T) (BENAZEPRILAT - UNII:JRM708L703), HYDROCHLOROTHIAZIDE (UNII: 0J48LPH2TH) (HYDROCHLOROTHIAZIDE - UNII:0J48LPH2TH)

থেকে পাওয়া:

Bryant Ranch Prepack

INN (International Name):

BENAZEPRIL HYDROCHLORIDE

রচনা:

BENAZEPRIL HYDROCHLORIDE 20 mg

প্রশাসন রুট:

ORAL

প্রেসক্রিপশন টাইপ:

PRESCRIPTION DRUG

থেরাপিউটিক ইঙ্গিত:

Benazepril hydrochloride and hydrochlorothiazide tablets are indicated for the treatment of hypertension. This fixed combination drug is not indicated for the initial therapy of hypertension (see DOSAGE AND ADMINISTRATION). Benazepril hydrochloride and hydrochlorothiazide is contraindicated in patients who are anuric. Benazepril hydrochloride and hydrochlorothiazide is also contraindicated in patients who are hypersensitive to benazepril, to any other ACE inhibitor, to hydrochlorothiazide, or to other sulfonamide-derived drugs. Hypersensitivity reactions are more likely to occur in patients with a history of allergy or bronchial asthma. Benazepril hydrochloride and hydrochlorothiazide is also contraindicated in patients with a history of angioedema with or without previous ACE inhibitor treatment. Benazepril hydrochloride and hydrochlorothiazide is contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). Do not administer benazepril hydrochloride and hydrochlorothiazide within 36 hours o

পণ্য সারাংশ:

NDC: 63629-2680-1: 30 Tablets in a BOTTLE NDC: 63629-2680-2: 90 Tablets in a BOTTLE NDC: 63629-2680-3: 100 Tablets in a BOTTLE NDC: 63629-2680-4: 60 Tablets in a BOTTLE

অনুমোদন অবস্থা:

Abbreviated New Drug Application

পণ্য বৈশিষ্ট্য

BENAZEPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE- BENAZEPRIL
HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE TABLET, FILM COATED
BRYANT RANCH PREPACK
----------
BENAZEPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE TABLETS
RX ONLY
PRESCRIBING INFORMATION
WARNING: FETAL TOXICITY
WHEN PREGNANCY IS DETECTED, DISCONTINUE BENAZEPRIL HYDROCHLORIDE AND
HYDROCHLOROTHIAZIDE AS SOON AS POSSIBLE.
DRUGS THAT ACT DIRECTLY ON THE RENIN-ANGIOTENSIN SYSTEM CAN CAUSE
INJURY
AND DEATH TO THE DEVELOPING FETUS (SEE WARNINGS, FETAL TOXICITY).
DESCRIPTION
Benazepril hydrochloride, USP is a white to off-white crystalline
powder, soluble (>100
mg/mL) in water, in ethanol, and in methanol. Benazepril
hydrochloride's chemical name
is 3-[[1-(ethoxycarbonyl)-3-phenyl-(1S)-propyl]amino]-2,3,4,5-
tetrahydro-2-oxo-1_H_-1-
(3S)-benzazepine-1-acetic acid monohydrochloride; its structural
formula is:
Its molecular formula is C
H
N O •HCl, and its molecular weight is 460.96.
Benazeprilat, the active metabolite of benazepril, is a nonsulfhydryl
angiotensin-
converting enzyme inhibitor. Benazepril is converted to benazeprilat
by hepatic cleavage
of the ester group.
Hydrochlorothiazide, USP is a white, or practically white, practically
odorless, crystalline
powder. It is slightly soluble in water; freely soluble in sodium
hydroxide solution, in _n_-
butylamine, and in dimethylformamide; sparingly soluble in methanol;
and insoluble in
ether, in chloroform, and in dilute mineral acids.
Hydrochlorothiazide's chemical name is
24
28
2
5
6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide; its structural
formula is:
Its molecular formula is C H ClN O S and its molecular weight is
297.73.
Hydrochlorothiazide is a thiazide diuretic.
The tablets are a combination of benazepril hydrochloride and
hydrochlorothiazide, USP.
They are formulated for oral administration with a combination of 5
mg, 10 mg, or 20
mg of benazepril hydrochloride and 6.25 mg, 12.5 mg, or 25 mg of
hydrochlorothiazide,
USP. The inactive ingredients of the tablets are colloidal sil