BANAMINE- flunixin meglumine injection

দেশ: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

Flunixin Meglumine (UNII: 8Y3JK0JW3U) (Flunixin - UNII:356IB1O400)

থেকে পাওয়া:

Merck Sharp & Dohme

INN (আন্তর্জাতিক নাম):

Flunixin Meglumine

রচনা:

Flunixin 50 mg in 1 mL

প্রশাসন রুট:

INTRAVENOUS

প্রেসক্রিপশন টাইপ:

PRESCRIPTION

থেরাপিউটিক ইঙ্গিত:

INDICATIONS Horse: BANAMINE (flunixin meglumine injection) is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse. It is also recommended for the alleviation of visceral pain associated with colic in the horse. Cattle: BANAMINE (flunixin meglumine injection) is indicated for the control of pyrexia associated with bovine respiratory disease, endotoxemia and acute bovine mastitis. BANAMINE is also indicated for the control of inflammation in endotoxemia. CONTRAINDICATIONS Horse: There are no known contraindications to this drug when used as directed. Intra-arterial injection should be avoided. Horses inadvertently injected intra-arterially can show adverse reactions. Signs can be ataxia, incoordination, hyperventilation, hysteria, and muscle weakness. Signs are transient and disappear without antidotal medication within a few minutes. Do not use in horses showing hypersensitivity to flunixin meglumine. Cattle: NSAIDs inhibit production of prostag

পণ্য সারাংশ:

HOW SUPPLIED BANAMINE (flunixin meglumine injection), 50 mg/ mL, is available in 100-mL (NDC 0061-0851-03), and 250-mL (NDC 0061-0851-04) multi-dose vials. Store at or below 25°C (77°F) Do not Freeze. See the in-use directions provided in the DOSE AND ADMINISTRATION section.

অনুমোদন অবস্থা:

New Animal Drug Application

পণ্য বৈশিষ্ট্য

BANAMINE- FLUNIXIN MEGLUMINE INJECTION
MERCK SHARP & DOHME
----------
BANAMINE
(FLUNIXIN MEGLUMINE INJECTION)
50 MG/ML
ONLY FOR INTRAVENOUS USE IN BEEF AND DAIRY CATTLE.
NOT FOR USE IN DRY DAIRY COWS AND VEAL CALVES.
FOR INTRAVENOUS AND INTRAMUSCULAR USE IN HORSES.
PRODUCT
INFORMATION
APPROVED BY FDA UNDER NADA # 101-479
CAUTION Federal law restricts this drug to use by or on the order of a
licensed
veterinarian.
DESCRIPTION Each milliliter of BANAMINE (flunixin meglumine injection)
contains 50 mg
flunixin (equivalent to 83 mg flunixin meglumine), 0.1 mg edetate
disodium, 2.5 mg
sodium formaldehyde sulfoxylate, 4.0 mg diethanolamine, 207.2 mg
propylene glycol;
5.0 mg phenol as preservative, hydrochloric acid, water for injection
qs.
PHARMACOLOGY Flunixin meglumine is a potent, non-narcotic,
nonsteroidal, analgesic
agent with anti-inflammatory and antipyretic activity. It is
significantly more potent than
pentazocine, meperidine, and codeine as an analgesic in the rat yeast
paw test.
_Horse:_ Flunixin is four times as potent on a mg-per-mg basis as
phenylbutazone as
measured by the reduction in lameness and swelling in the horse.
Plasma half-life in
horse serum is 1.6 hours following a single dose of 1.1 mg/kg.
Measurable amounts are
detectable in horse plasma at 8 hours postinjection.
_Cattle:_ Flunixin meglumine is a weak acid (pKa=5.82) which exhibits
a high degree of
plasma protein binding (approximately 99%).
However, free (unbound) drug appears to
readily partition into body tissues (V
predictions range from 297 to 782 mL/kg.
Total
body water is approximately equal to 570 mL/kg).
In cattle, elimination occurs primarily
through biliary excretion.
This may, at least in part, explain the presence of multiple
peaks in the blood concentration/time profile following IV
administration.
In healthy cattle, total body clearance has been reported to range
from 90 to 151
mL/kg/hr.
These studies also report a large discrepancy between the volume of
distribution at steady state (V
) and the volume of distribution associat