দেশ: অস্ট্রেলিয়া
ভাষা: ইংরেজি
সূত্র: Department of Health (Therapeutic Goods Administration)
glimepiride
Alphapharm Pty Ltd
Glimepiride
Registered
AYLIDE _contains the active ingredient glimepiride_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Aylide. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Aylide against the benefits expected for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, TALK TO YOUR DOCTOR OR PHARMACIST. PLEASE READ THIS LEAFLET CAREFULLY AND KEEP THIS LEAFLET WITH YOUR MEDICINE. You may need to read it again. WHAT AYLIDE IS USED FOR Aylide is used to control high blood sugar levels in people with type 2 diabetes mellitus. This type of diabetes is also known as non-insulin-dependent diabetes mellitus (NIDDM) or maturity onset diabetes. Aylide is used when diet and exercise are not enough to control your condition. However, as Aylide does not replace these, your doctor will suggest that you continue with your diet and exercise programs, while you are taking Aylide. Aylide contains the active ingredient glimepiride, which belongs to a group of medicines called sulfonylureas. These medicines work to lower blood sugar levels by causing your pancreas to release more insulin into the blood stream. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY AYLIDE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed Aylide for another reason. Aylide is not recommended for use in children, as its safety and effectiveness in this age group has not been established. Aylide is available only with a doctor's prescription. There is no evidence that Aylide is addictive. BEFORE YOU TAKE AYLIDE _WHEN YOU MUST NOT TAKE IT_ DO NOT TAKE AYLIDE IF YOU ARE ALLERGIC TO: • medicines containing glimepiride (e.g. Amaryl) • any other sulfonylureas • related medicines such as sulfur antibiotics (e.g. sulfonamides) or thiazide diuretics • any of the ingredients listed at the end of this leaflet. Some of the symptoms of an allergic reaction সম্পূর্ণ নথি পড়ুন
AYLIDE ® _Glimepiride _ PRODUCT INFORMATION NAME OF THE MEDICINE Active ingredient: Glimepiride Chemical name: trans-1-{4-[2- (3-ethyl-4-methyl- 2-oxo-3-pyrroline- 1 carboxamido) ethyl]phenylsulfonyl}-3- (4-methylcyclohexyl) urea Structural formula: Molecular formula: C 24 H 34 N 4 0 5 S Molecular weight: 490.62 CAS Registry No.: 93479-97-1 DESCRIPTION Glimepiride is a member of the sulfonylurea group of oral antidiabetic agents. It is a white odourless, crystalline powder, practically insoluble in methanol and water, slightly soluble in ethanol and sparingly soluble in methylene chloride. Aylide is available as 1 mg, 2 mg, 3 mg and 4 mg tablets containing glimepiride as the active ingredient. Aylide tablets also contain the following inactive ingredients: lactose monohydrate, povidone, cellulose - microcrystalline, magnesium stearate, sodium starch glycollate, iron oxide red CI77491 (1 mg tablet only), iron oxide yellow CI77492 (2 mg and 3 mg tablets) and indigo carmine CI73015 (2 mg and 4 mg tablets). PHARMACOLOGY PHARMACODYNAMICS MECHANISM OF ACTION Glimepiride is a sulfonylurea antidiabetic agent which decreases blood glucose concentrations. The primary mechanism of action of glimepiride appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. Glimepiride acts in concert with glucose by improving the sensitivity of beta cells to physiological glucose stimulus, resulting in insulin secretion in the rhythm of meals. In addition, extrapancreatic effects (e.g. reduction of basal hepatic glucose production and increased peripheral tissue sensitivity to insulin and glucose uptake) may also play a limited role in the activity of glimepiride. In non-fasting diabetic patients, the hypoglycaemic action of a single dose of glimepiride persists for 24 hours. Evidence from _ in vitro_ and animal studies suggests that there is lower glucagon secretion with glimepiride than glibenclamide and this may give rise to a prolonged reduction of blood glucose levels without increased pl সম্পূর্ণ নথি পড়ুন