APO-LERCANIDIPINE lercanidipine hydrochloride 10 mg film coated tablet bottle

Country: অস্ট্রেলিয়া

ভাষা: ইংরেজি

সূত্র: Department of Health (Therapeutic Goods Administration)

সক্রিয় উপাদান:

lercanidipine hydrochloride, Quantity: 10 mg

থেকে পাওয়া:

Arrotex Pharmaceuticals Pty Ltd

INN (International Name):

Lercanidipine hydrochloride

ফার্মাসিউটিকাল ফর্ম:

Tablet, film coated

রচনা:

Excipient Ingredients: croscarmellose sodium; purified talc; hypromellose; microcrystalline cellulose; macrogol 8000; magnesium stearate; butylated hydroxytoluene; lactose monohydrate; titanium dioxide; iron oxide yellow

প্রশাসন রুট:

Oral

প্যাকেজ ইউনিট:

30, 500, 100

প্রেসক্রিপশন টাইপ:

(S4) Prescription Only Medicine

থেরাপিউটিক ইঙ্গিত:

Lercanidipine is indicated for the treatment of hypertension.

পণ্য সারাংশ:

Visual Identification: Yellow coloured, film coated, round shaped, biconvex tablets engraved 'APO' on one side and scoreline on the other side.; Container Type: Bottle; Container Material: HDPE; Container Life Time: 24 Months; Container Temperature: Store below 25 degrees Celsius; Container Closure: Child resistant closure

অনুমোদন অবস্থা:

Licence status A

অনুমোদন তারিখ:

2010-08-12

পণ্য বৈশিষ্ট্য

Product Information – Australia
APO- Lercanidipine Tablets
Page 1
APO-LERCANIDIPINE TABLETS
NAME OF THE MEDICINE
Lercanidipine Hydrochloride.
Chemical Name:
3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,
6-dimethyl-4-(3-nitrophenyl)-2-[(3,3-
diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester
hydrochloride.
Structural Formula:
HCl
Molecular Formula:
C
36
H
42
ClN
3
O
6
Molecular Weight:
648.2 (free base: 611.7)
CAS Registry Number:
132866-11-6
DESCRIPTION
Lercanidipine is a dihydropyridine derivative. It is a racemate due to
the presence of a chiral carbon atom
at position 4 of the 1,4-dihydropyridine ring.
Lercanidipine hydrochloride is a yellow amorphous powder, readily
soluble in chloroform and methanol,
practically insoluble in water. Octanol:water partition coefficient
(LogP): 6.4.
Each tablet contains 10 mg or 20 mg lercanidipine hydrochloride as the
active ingredient.
In addition, each tablet contains the following inactive ingredients:
Cellulose – microcrystalline , lactose
monohydrate, croscarmellose sodium, butylated hydroxytoluene,
magnesium stearate, hypromellose,
macrogol 8000, titanium dioxide, purified talc, yellow iron oxide (10
mg only) and red iron oxide (20 mg
only).
`
PHARMACOLOGY
PHARMACOLOGICAL ACTIONS
Lercanidipine
is
a
calcium
antagonist
of
the
dihydropyridine
group
and
selectively
inhibits
the
transmembrane influx of calcium into cardiac and vascular smooth
muscle, with a greater effect on vascular
smooth muscle than on cardiac smooth muscle. The antihypertensive
action is due to a direct relaxant
effect on vascular smooth muscle which lowers total peripheral
resistance and hence blood pressure.
Lercanidipine has a prolonged antihypertensive activity because of its
high membrane partition coefficient.
It is devoid of negative inotropic effects and its vascular
selectivity is due to its voltage dependent calcium
antagonist activity. Since the vasodilatation induced by lercanidipine
hydrochloride is gradual in onset,
acute hypotension with reflex tachycardia has rarely been observ