Anandron

দেশ: অস্ট্রেলিয়া

ভাষা: ইংরেজি

সূত্র: Department of Health (Therapeutic Goods Administration)

সক্রিয় উপাদান:

Nilutamide

থেকে পাওয়া:

Sanofi-Aventis Australia Pty Ltd

শ্রেণী:

Medicine Registered

তথ্য লিফলেট

ANANDRON(R)
1
ANANDRON(R)
(an-and-ron)
_Nilutamide (nill-ute-am-ide)_
CONSUMER MEDICINE INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Anandron. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Anandron
against the benefits Anandron is
expected to have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING ANANDRON, ASK YOUR DOCTOR
OR PHARMACIST.
Keep this leaflet with the medicine.
You may need to read it again.
WHAT ANANDRON IS USED
FOR
Anandron is a medicine for treating
prostate cancer in men. It contains
the active ingredient Nilutamide.
Anandron belongs to a family of
medicines called non-steroidal
anti-androgens. These medicines
work by blocking the effect of
androgen hormones that are naturally
produced by your body. Prostate
cancer cells are dependent on these
hormones, and blocking their effect
is intended to stop the growth of the
cancer.
Anandron is more effective when
used at the same time as other
medicines known generally as LHRH
agonists or, alternatively, following
surgery designed to treat prostate
cancer.
Your doctor may have prescribed
Anandron for another reason.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY ANANDRON HAS
BEEN PRESCRIBED FOR YOU.
Anandron is available only with a
doctor's prescription.
BEFORE YOU TAKE
ANANDRON
_WHEN YOU MUST NOT TAKE IT_
Anandron must only be taken by
men. It is not suitable for women or
children.
DO NOT TAKE ANANDRON IF:
-
YOU HAVE AN ALLERGY TO:
NILUTAMIDE OR ANY OF THE OTHER
INGREDIENTS LISTED AT THE END OF THIS
LEAFLET (SEE PRODUCT DESCRIPTION).
Symptoms of an allergic reaction to
these medicines may include:
*
asthma, wheezing or shortness of
breath
*
swelling of the face, lips or
tongue which may cause
difficulty in swallowing or
breathing
*
hives, i

পণ্য বৈশিষ্ট্য

PRODUCT INFORMATION 
ANANDRON
®

NAME OF THE MEDICINE 
NON-PROPRIETARY NAME 
Nilutamide 
CHEMICAL STRUCTURE 

DESCRIPTION 
Nilutamide is a non-steroidal orally-active specific antiandrogen. The
compound is a white to off-
white powder with the
chemical name of 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-
imidazolidinedione (MW = 317.2, CAS 63612-50-0). 
Each ANANDRON tablet contains nilutamide 150 mg as active
ingredient. The tablets also contain 
lactose, maize starch, povidone, sodium docusate, magnesium stearate
and talc as excipients. 
PHARMACOLOGY 
PHARMACODYNAMICS  
As growth and differentiation of prostate cancer cells
are dependent on the presence of adequate 
concentrations of circulating androgens of testicular and adrenal
origin, the primary goal in the 
systemic treatment of metastatic prostate cancer is the suppression
and/or blockade of androgenic 
stimulation. 
Nilutamide is not a cytotoxic drug. Nilutamide acts by
competing at the level of the prostatic 
androgen receptor for binding of endogenous steroids and
by inhibiting androgen uptake. 
Nilutamide interacts only with the androgen receptor and not with
other steroid hormone receptors 
(oestrogen, progestin, mineralo- or gluco-corticoid), hence it lacks
other hormonal or antihormonal 
activities. 
In addition to antagonising the effects of androgens on prostate
tissue, nilutamide also acts at 
other sites which have androgen receptors including the hypothalamus
and pituitary. By 
interrupting the negative feedback of androgens at the
hypothalamo-pituitary level, nilutamide 
induces a secondary increase in gonadotropin and androgen
secretion which overcomes part of 
the blocking effect. It is therefore advisable to inhibit
testosterone secretion by either surgical or 
medical castration. Combining nilutamide with surgical (bilateral
orchidectomy) or chemical (LHRH 
agonist) castration provides a more complete an