Amprace

দেশ: অস্ট্রেলিয়া

ভাষা: ইংরেজি

সূত্র: Department of Health (Therapeutic Goods Administration)

সক্রিয় উপাদান:

Enalapril maleate

থেকে পাওয়া:

Merck Sharp & Dohme Australia Pty Ltd

শ্রেণী:

Medicine Registered

তথ্য লিফলেট

AMPRACE
®

_Enalapril maleate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about AMPRACE. It does
not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking AMPRACE
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT AMPRACE IS
USED FOR
AMPRACE lowers high blood
pressure, which doctors call
hypertension. It is also used to treat
heart failure.
HYPERTENSION:
Everyone has blood pressure. This
pressure helps get your blood all
around your body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
hypertension (high blood pressure)
when your blood pressure stays
higher than is needed, even when you
are calm and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. If high
blood pressure is not treated it can
lead to serious health problems. You
may feel fine and have no symptoms,
but eventually hypertension can
cause stroke, heart disease and
kidney failure. AMPRACE helps to
lower your blood pressure.
HEART FAILURE:
Heart failure means that the heart
muscle cannot pump blood strongly
enough to supply all the blood
needed throughout the body. Heart
failure is not the same as heart attack
and does not mean that the heart
stops working. Heart failure may
start off with no symptoms, but as the
condition progresses, patients may
feel short of breath or may get tired
easily after light physical activity
such as walking. Some patients may
wake up short of breath at night.
Fluid may collect in different parts of
the body, often first noticed as
swollen ankles and feet.
AMPRACE helps to tre

পণ্য বৈশিষ্ট্য

IPC-MK0421-MF-112012 

1 
Copyright © 2011 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Whitehouse Station, NJ, USA. All Rights 
Reserved. A130403 V4 
PRODUCT INFORMATION 

Tablets 

AMPRACE
®

(enalapril maleate) 

INTRODUCTION 

AMPRACE  (enalapril  maleate)  is  the  maleate  salt  of  enalapril,  a  derivative  of  two  amino  acids, 
L-alanine  and  L-proline.  Following  oral  administration,  enalapril  is  rapidly  absorbed  and  then 
hydrolysed to enalaprilat, which is a specific, long-acting,
angiotensin converting enzyme inhibitor. 

DESCRIPTION 

AMPRACE tablets contain the maleate salt of enalapril, the ethyl ester of the parent diacid, enalaprilat.  
Enalapril maleate is chemically described as 
(S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline,
(Z)-2-butenedioate salt (1:1). 

It  lacks  a  sulphydryl  group.    Its  empirical  formula  is  C20  H28  N2  O5.C4  H4  O4,  and  its  structural 
formula is: 

CHCOOH
CHCOOH
N
COOH
CO
NHCH
CH
3
CH
2
CH
2
CH
COOCH
2
CH
3

Enalapril  maleate  is  a  white  to  off-white  crystalline  powder  with  a  molecular  weight  of  492.53.    It  is 
sparingly soluble in water, soluble in ethanol, and freely soluble
in methanol and dimethylformamide. 

AMPRACE Tablets (10 mg and 20 mg) contain the following excipients; sodium bicarbonate, lactose, 
starch-maize, starch-pregelatinised maize, magnesium stearate. The 10 mg tablets also contain iron-
oxide red, while the 20 mg tablets contain iron-oxide red and
iron-oxide yellow. 

CLINICAL PHARMACOLOGY 

Enalapril  maleate  is  a  pro-drug  which  when  administered  orally  is  hydrolysed  to  release  the  active 
converting enzyme inhibitor enalaprilat.  The liver
appe