VERAPAMIL HYDROCHLORIDE tablet film coated extended release

Страна: САЩ

Език: английски

Източник: NLM (National Library of Medicine)

Активна съставка:

VERAPAMIL HYDROCHLORIDE (UNII: V3888OEY5R) (VERAPAMIL - UNII:CJ0O37KU29)

Предлага се от:

St Marys Medical Park Pharmacy

INN (Международно Name):

VERAPAMIL HYDROCHLORIDE

Композиция:

VERAPAMIL HYDROCHLORIDE 240 mg

Вид предписание :

PRESCRIPTION DRUG

Статус Оторизация:

Abbreviated New Drug Application

Данни за продукта

VERAPAMIL HYDROCHLORIDE - VERAPAMIL HYDROCHLORIDE TABLET, FILM COATED,
EXTENDED
RELEASE
ST MARYS MEDICAL PARK PHARMACY
----------
VERAPAMIL HYDROCHLORIDE EXTENDED-RELEASE TABLETS USP
RX ONLY
DESCRIPTION
Verapamil hydrochloride extended-release tablets USP are calcium ion
influx inhibitor (slow channel
blocker or calcium ion antagonist). Verapamil hydrochloride
extended-release tablets USP are available
for oral administration as brown colored, oval, biconvex, film-coated
tablets containing 120 mg
verapamil hydrochloride USP, as brown colored, oval, biconvex,
film-coated tablets containing 180 mg
verapamil hydrochloride USP, and as brown colored, oval, biconvex,
film-coated tablets containing 240
mg verapamil hydrochloride USP. The tablets are designed for
sustained-release of the drug in the
gastrointestinal tract, sustained-release characteristics are not
altered when the tablet is divided in half.
The structural formula of verapamil HCl USP is given below:
C
H N O ·HCl..........M.W. 491.06
Benzeneacetonitrile,
α[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-
dimethoxy-α-(1-
methylethyl) hydrochloride
Verapamil HCl USP is an almost white, crystalline powder, practically
free of odor, with a bitter taste.
It is soluble in water, chloroform and methanol. Verapamil HCl USP is
not chemically related to other
cardioactive drugs.
In addition to verapamil HCl USP, the verapamil hydrochloride
extended-release tablets USP contain
the following ingredients: colloidal silicon dioxide, sodium alginate,
hypromellose, magnesium
stearate, microcrystalline cellulose, povidone, polyethylene glycol
and titanium dioxide. The following
are the color additives per tablet strength:
Strength (mg)
Color Additive(s)
120
Ferric Oxide Yellow, Ferric Oxide Red and Ferric Oxide Black
180
Ferric Oxide Yellow, Ferric Oxide Red and Ferric Oxide Black
240
Ferric Oxide Yellow, Ferric Oxide Red and Ferric Oxide Black
Verapamil hydrochloride extended-release tablets USP, 120 mg, 180 mg
and 240 mg meet USP
Dissolution Test 1.
CLINICAL