Страна: Сингапур
Език: английски
Източник: HSA (Health Sciences Authority)
Tamsulosin eqv Tamsulosin hydrochloride
TEVA PHARMACEUTICAL INVESTMENTS SINGAPORE PTE. LTD.
G04CA02
TABLET, FILM COATED, EXTENDED RELEASE
Tamsulosin eqv Tamsulosin hydrochloride 0.40 mg
ORAL
Prescription Only
Teva Pharmaceutical Works Private Limited Company
ACTIVE
2021-05-11
TAMSULOSIN-TEVA PROLONGED RELEASE FILM-COATED TABLET 400MCG ACTIVE SUBSTANCE Tamsulosin hydrochloride DESCRIPTION Tamsulosin-Teva is a film-coated, prolonged release tablet containing 400 mcg tamsulosin hydrochloride, an α1-adrenoceptor blocking agent. It has a high affinity for the α1A- receptor subtype predominantly present in the human prostate. The chemical structure of tamsulosin hydrochloride is: The chemical name is (R)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2- methoxybenzenesulfonamide, monohydrochloride. The molecular weight is 444.98. The CAS registry number is CAS-106463-17-6 (hydrochloride). Tamsulosin-Teva also contains cellulose microcrystalline, polyethylene oxide, colloidal anhydrous silica, magnesium stearate, hypromellose, titanium dioxide, macrogol 8000, iron oxide yellow, iron oxide red. None of the excipients is derived from animal sources. Tamsulosin hydrochloride is sparingly soluble in water (1:85) and slightly soluble in alcohol. It is stable in an acid environment. PHARMACOLOGY The tone of the human prostate smooth muscle is maintained primarily by noradrenaline released from adrenergic nerves and stimulating post-junctional α1-adrenoceptors. This provides the rationale for the use of α1-adrenoceptor antagonists for lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). PHARMACODYNAMICS Pharmacological studies have established that tamsulosin is a selective, potent and competitive α1-adrenoceptor antagonist and that it has a greater affinity for the α1A- receptor subtype, predominantly present in the human prostate. α1-adrenoceptor antagonists generally can reduce blood pressure by lowering peripheral resistance. However, no reduction in blood pressure of any clinical significance was observed during studies with Tamsulosin. The binding of tamsulosin to α1-adrenoceptors in the prostate results in relaxation of prostate smooth muscle followed by improvements in urodynamics. Thus, Tamsulosin increases maximum urinary flow rate by reducing smooth mus Прочетете целия документ