Страна: Малайзия
Език: английски
Източник: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMYLMETACRESOL; LIGNOCAINE HCL/LIDOCAINE HCL; DICHLOROPHENYLCARBINOL
RB (HEALTH) MALAYSIA SDN BHD
AMYLMETACRESOL; LIGNOCAINE HCL/LIDOCAINE HCL; DICHLOROPHENYLCARBINOL
0 gm 16 Tablet Tablets
Reckitt Benckiser Healthcare Manufacturing (Thailand) Limited
STREPSILS ® MAX PLUS LOZENGE COMPOSITION: Each lozenge contains: Amylmetacresol 0.6mg Dichlorophenylcarbinol 1.2mg Lignocaine hydrochloride 10.0mg DESCRIPTION Pale blue-green, circular lozenge with a characteristic aromatic flavour. Available in unit cartons containing 2 blisters of 8 lozenges. PHARMACODYNAMICS 2,4-Dichlorobenzyl alcohol (Dichlorophenylcarbinol) and Amylmetacresol have antiseptic properties. Lidocaine (Lignocaine) is a local anaesthetic of the amide type, acting to produce reversible loss of sensation by preventing or diminishing the generation and transmission of sensory nerve impulses near the site of application. Depolarisation of the neuronal membrane and ion exchange are reversibly inhibited. It provides an anaesthetic effect by blocking neuronal transmission. PHARMACOKINETICS Lidocaine is readily absorbed from mucous membranes. The plasma elimination half-life is about 2 hours. Lidocaine undergoes significant first pass metabolism in the liver and is rapidly de-ethylated to the active metabolites including glycinexylidide. Less than 10% is excreted unchanged by the kidneys. The metabolites are also excreted in the urine. 2,4-Dichlorobenzyl alcohol (Dichlorophenyl- carbinol) is metabolised by the liver to form hippuric acid which is excreted in the urine. No data available on amylmetacresol metabo- lism and elimination. INDICATION For the symptomatic relief of mouth and throat infections including severe sore throat. DOSAGE AND ADMINISTRATION For Oral Use only. Adults and children over 12 years - one lozenge to be sucked every 2 hours as required. Not more than 8 lozenges to be sucked in any 24-hour period. Not recommended for children under 12 years of age. CONTRAINDICATION Strepsils Max Plus lozenge are contraindicated in persons who have previously shown hypersensitivity to any of the active ingredients or to any of the excipients. A history of allergy to local anaesthetics of the amide-type. In patients who have a history of or are suspected to have methaemoglobinaemia. Patients sufferi Прочетете целия документ