Retrovir

Страна: Австралия

Език: английски

Източник: Department of Health (Therapeutic Goods Administration)

Активна съставка:

Zidovudine

Предлага се от:

ViiV Healthcare Pty Ltd

Клас:

Medicine Registered

Листовка

RETROVIR
®

_CAPSULES AND SYRUP_
_zidovudine_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET?
Please read this leaflet carefully
before you start Retrovir.
This leaflet answers some common
questions about Retrovir. It does not
contain all of the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Retrovir
against the benefits this medicine is
expected to have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT RETROVIR IS USED
FOR
Retrovir contains zidovudine which
belongs to a group of medicines
called antiretrovirals.
Retrovir is used, alone or with other
antiretrovirals, to slow down the
progression of human immuno-
deficiency virus (HIV) infection,
which can lead to Acquired Immune
Deficiency Syndrome (AIDS) and
other related illnesses (e.g. AIDS-
related Complex or ARC).
Retrovir does not cure AIDS or HIV
infection, but slows production of
human immunodeficiency virus. In
this way it stops ongoing damage to
the body's immune system, which
fights infection.
Retrovir does not reduce your risk of
passing HIV infection to others. You
will still be able to pass on the HIV
virus by sexual activity or by passing
on blood or bodily secretions, which
carry the HIV virus. You should
continue to take all appropriate
precautions.
While taking Retrovir and/or any
other therapy for HIV disease, you
may continue to develop other
infections and other complications of
HIV infection. You should keep in
regular contact with your doctor.
Retrovir has been extensively studied
but for limited periods of time. The
long-term risks and benefits of taking
Retrovir are not known; especially in
patients without symptoms of HIV
infection, or with early HIV disease.
Your doctor may have prescribed
Retrovir for another reason. Ask your
doctor if you have any questions
about why Re

Данни за продукта

1 

PRODUCT INFORMATION 

RETROVIR® CAPSULES AND SYRUP 

NAME OF THE MEDICINE:  

Retrovir (zidovudine). The chemical name of zidovudine
is 3'-azido-3'-deoxythymidine; it has 
the following formula:  

DESCRIPTION: 

Zidovudine  is a white to
off-white, odourless, crystalline solid with a
molecular weight of 
267.24 and the molecular formula C10H13N504. Retrovir is the
brand name for zidovudine 
(formerly called  azidothymidine (AZT)), an
antiretroviral drug active against human 
immunodeficiency virus (HIV).  

PHARMACOLOGY: 

Zidovudine is an inhibitor of the _in vitro_  replication
of some retroviruses including HIV (also 
known as HTLVIII, LAV or ARV). This drug is a thymidine
analogue in which the 3'-hydroxy (-
OH) group is replaced by an azido (-N3) group. Cellular thymidine kinase converts zidovudine 
into zidovudine monophosphate. The monophosphate
is further converted into the 
diphosphate by cellular thymidylate kinase and to
the triphosphate derivative by other cellular 
enzymes.  Zidovudine triphosphate interferes with the
HIV viral RNA dependent DNA 
polymerase (reverse transcriptase) and
thus inhibits viral replication. Zidovudine triphosphate 
also inhibits cellular 
a-DNA polymerase, but at concentrations 100-fold higher than
those 
required to inhibit reverse transcriptase. _In vitro_, zidovudine
triphosphate has been shown to 
be incorporated into growing chains of DNA by viral reverse
transcriptase. When 
incorporation by the viral enzyme occurs, the DNA chain
is terminated. Studies in cell culture 
suggest that zidovudine incorporation by cellular 
a-DNA polymerase may occur, but only to a 
very small extent and not in all test systems. Chain termination has not been demonstrated 
with cellular 
a-DNA polymerase. 

MICROBIOLOGY:  The relationship
bet