POTASSIUM CHLORIDE tablet, film coated, extended release

Страна: САЩ

Език: английски

Източник: NLM (National Library of Medicine)

Активна съставка:

POTASSIUM CHLORIDE (UNII: 660YQ98I10) (POTASSIUM CATION - UNII:295O53K152)

Предлага се от:

Clinical Solutions Wholesale

INN (Международно Name):

POTASSIUM CHLORIDE

Композиция:

POTASSIUM CHLORIDE 600 mg

Начин на приложение:

ORAL

Вид предписание :

PRESCRIPTION DRUG

Терапевтични показания:

BECAUSE OF REPORTS OF INTESTINAL AND GASTRIC ULCERATION AND BLEEDING WITH EXTENDED-RELEASE POTASSIUM CHLORIDE PREPARATIONS, THESE DRUGS SHOULD BE RESERVED FOR THOSE PATIENTS WHO CANNOT TOLERATE OR REFUSE TO TAKE LIQUID OR EFFERVESCENT POTASSIUM PREPARATIONS OR FOR PATIENTS IN WHOM THERE IS A PROBLEM OF COMPLIANCE WITH THESE PREPARATIONS. - For the therapeutic use of patients with hypokalemia, with or without metabolic alkalosis; in digitalis intoxication; and in patients with hypokalemic familial periodic paralysis. If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia. - For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias. The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patien

Каталог на резюме:

Film-coated Potassium Chloride 8 mEq (dark-blue, debossed with "USL 8"), Potassium Chloride 10 mEq (white, debossed with "USL 10"), round tablets containing: Store at controlled room temperature, 15-30°C (59-86°F). Protect from light and moisture. Dispense in a tight container with child-resistant closure.

Статус Оторизация:

New Drug Application

Данни за продукта

POTASSIUM CHLORIDE- POTASSIUM CHLORIDE TABLET, FILM COATED, EXTENDED
RELEASE
CLINICAL SOLUTIONS WHOLESALE
----------
POTASSIUM
CHLORIDE
EXTENDED-RELEASE TABLETS, USP
8 MEQ AND 10 MEQ
DESCRIPTION
Potassium Chloride Extended-release Tablets, USP are a solid oral
dosage form of potassium chloride.
Each contains 600 mg or 750 mg of potassium chloride equivalent to 8
mEq or 10 mEq of potassium in
a wax matrix tablet. This formulation is intended to provide an
extended-release of potassium from the
matrix to minimize the likelihood of producing high, localized
concentrations of potassium within the
gastrointestinal tract.
Potassium Chloride Extended-release Tablets are an electrolyte
replenisher. The chemical name is
potassium chloride, and the structural formula is KCl. Potassium
chloride, USP is a white, granular
powder or colorless crystals. It is odorless and has a saline taste.
Its solutions are neutral to litmus. It is
freely soluble in water and insoluble in alcohol.
CLINICAL PHARMACOLOGY
The potassium ion is the principal intracellular cation of most body
tissues. Potassium ions participate
in a number of essential physiological processes including the
maintenance of intracellular tonicity, the
transmission of nerve impulses, the contraction of cardiac, skeletal
and smooth muscle and the
maintenance of normal renal function.
The intracellular concentration of potassium is approximately 150 to
160 mEq per liter. The normal
adult plasma concentration is 3.5 to 5 mEq per liter. An active ion
transport system maintains this gradient
across the plasma membrane.
Potassium is a normal dietary constituent and under steady state
conditions the amount of potassium
absorbed from the gastrointestinal tract is equal to the amount
excreted in the urine. The usual dietary
intake of potassium is 50 to 100 mEq per day.
Potassium depletion will occur whenever the rate of potassium loss
through renal excretion and/or loss
from the gastrointestinal tract exceeds the rate of potassium intake.
Such depletion usually develops
slowly