PMS-LISINOPRIL TABLET

Страна: Канада

Език: английски

Източник: Health Canada

Активна съставка:

LISINOPRIL

Предлага се от:

PHARMASCIENCE INC

АТС код:

C09AA03

INN (Международно Name):

LISINOPRIL

дозиране:

10MG

Лекарствена форма:

TABLET

Композиция:

LISINOPRIL 10MG

Начин на приложение:

ORAL

Броя в опаковка:

100

Вид предписание :

Prescription

Терапевтична област:

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

Каталог на резюме:

Active ingredient group (AIG) number: 0121550001; AHFS:

Статус Оторизация:

APPROVED

Дата Оторизация:

2007-10-17

Данни за продукта

PRODUCT MONOGRAPH
PR
PMS-LISINOPRIL
Lisinopril Tablets, USP
5 mg, 10 mg and 20 mg
ANGIOTENSIN CONVERTING ENZYME INHIBITOR
PHARMASCIENCE INC.
6111 Royalmount Ave., Suite 100
Montreal, Quebec
H4P 2T4
www.pharmascience.com
Date of Revision:
July 11, 2017
Submission Control No: 206872
_pms-LISINOPRIL Product Monograph _
_Page 2 of 41_
PRODUCT MONOGRAPH
PR
PMS-LISINOPRIL
Lisinopril Tablets, USP
5 mg, 10 mg and 20 mg
Angiotensin Converting Enzyme Inhibitor
ACTIONS AND CLINICAL PHARMACOLOGY
Lisinopril is an angiotensin converting enzyme (ACE) inhibitor which
is used in the treatment of
hypertension, congestive heart failure and following myocardial
infarction in hemodynamically
stable patients.
ACE is a peptidyl dipeptidase which catalyzes the conversion of
angiotensin I to the pressor
substance, angiotensin II. Inhibition of ACE results in decreased
plasma angiotensin II, which
leads to increased plasma renin activity (due to removal of negative
feedback of renin release)
and decreased aldosterone secretion. Although the latter decrease is
small, it results in a small
increase in serum potassium. In patients treated with lisinopril and a
thiazide diuretic there was
essentially no change in serum potassium (see PRECAUTIONS).
ACE is identical to kininase II. Thus, lisinopril may also block the
degradation of bradykinin, a
potent vasodilator peptide. However, the role that this plays in the
therapeutic effects of lisinopril
is unknown.
While the mechanism through which lisinopril lowers blood pressure is
believed to be primarily
the suppression of the renin-angiotensin-aldosterone system (RAAS),
lisinopril also lowers blood
pressure in patients with low-renin hypertension.
PHARMACODYNAMICS
HYPERTENSION
_ADULTS_: Administration of lisinopril to patients with hypertension
results in a reduction of both
supine and standing blood pressure. Abrupt withdrawal of lisinopril
has not been associated with
a rapid increase in blood pressure. In most patients studied, after
oral administration of an
individual dose of lisinopril, the