PMS-CAPTOPRIL - TAB 25MG TABLET

Страна: Канада

Език: английски

Източник: Health Canada

Активна съставка:

CAPTOPRIL

Предлага се от:

PHARMASCIENCE INC

АТС код:

C09AA01

INN (Международно Name):

CAPTOPRIL

дозиране:

25MG

Лекарствена форма:

TABLET

Композиция:

CAPTOPRIL 25MG

Начин на приложение:

ORAL

Броя в опаковка:

100/1000

Вид предписание :

Prescription

Терапевтична област:

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

Каталог на резюме:

Active ingredient group (AIG) number: 0114954001; AHFS:

Статус Оторизация:

APPROVED

Дата Оторизация:

1998-06-17

Данни за продукта

PRODUCT MONOGRAPH
PR
PMS-CAPTOPRIL
Captopril Tablets, USP
Film-Coated Tablets
12.5, 25, 50 and 100 mg
ANGIOTENSIN-CONVERTING ENZYME INHIBITOR
PHARMASCIENCE INC.
DATE OF REVISION:
6111 Royalmount Ave., Suite100
September 7, 2016
Montreal, Canada
H4P 2T4
www.pharmascience.com
Submission Control No: 197598
_pms-CAPTOPRIL Product Monograph _
_ _
_Page 2 of 31 _
PRODUCT MONOGRAPH
NAME OF DRUG
PR
PMS-CAPTOPRIL
Captopril Tablets, USP
Film-Coated Tablets
12.5, 25, 50 and 100 mg
THERAPEUTIC CLASSIFICATION
Angiotensin-Converting Enzyme Inhibitor
ACTIONS AND CLINICAL PHARMACOLOGY
Captopril is an angiotensin converting enzyme inhibitor which is used
in the treatment of
hypertension and heart failure.
The mechanism of action of captopril has not yet been fully
elucidated. It appears to lower blood
pressure and be an adjunct in the therapy of congestive heart failure
primarily through suppression
of the renin-angiotensin-aldosterone system; however, there is no
consistent correlation between
renin levels and response to the drug. Renin, an enzyme synthesized by
the kidneys, is released into
the circulation where it acts on a plasma globulin substrate to
produce angiotensin I, a relatively
inactive decapeptide. Angiotensin I is then converted by angiotensin
converting enzyme (ACE) to
angiotensin II, a potent endogenous vasoconstrictor substance.
Angiotensin II also stimulates
aldosterone secretion from the adrenal cortex, thereby contributing to
sodium and fluid retention.
Captopril prevents the conversion of angiotensin I to angiotensin II
by inhibition of ACE, a
peptidyldipeptide carboxy hydrolase.
ACE is identical to "bradykininase" and captopril may also interfere
with the degradation of the
vasodepressor peptide, bradykinin. However, the effectiveness of
captopril in therapeutic doses
appears to be unrelated to potentiation of the actions of bradykinin.
Increased concentrations of
bradykinin or prostaglandin E2 may also have a role in the therapeutic
effect of captopril, especially
in low-renin hypertension.
Inhibition of