PENICILLIN V POTASIUM tablet

Страна: САЩ

Език: английски

Източник: NLM (National Library of Medicine)

Активна съставка:

PENICILLIN V POTASSIUM (UNII: 146T0TU1JB) (PENICILLIN V - UNII:Z61I075U2W)

Предлага се от:

REMEDYREPACK INC.

Начин на приложение:

OROPHARYNGEAL

Вид предписание :

PRESCRIPTION DRUG

Терапевтични показания:

Penicillin V potassium tablets are indicated in the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response. NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and arthritis should not be treated with penicillin V during the acute stage. Indicated surgical procedures should be performed. The following infections will usually respond to adequate dosage of penicillin V. Mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas. NOTE: Streptococci in groups A, C, G, H, L, and M are very sensitive to penicillin. Other groups, including group D (enterococcus), are resistant. Mild to moderately severe infections of the respiratory tract. Mild infections of the skin and soft tissues. NOTE: Reports indicate an increasing number of strains of staphylococci resistant to penicillin G, emphasizing the need for culture an

Каталог на резюме:

Penicillin-VK Tablets (Penicillin V Potassium Tablets USP), 500 mg (800,000 units) are oblong, biconvex white tablets, debossed PVK 500 on one side and GG 950 on the reverse side and break scored on both sides. NDC: 70518-2192-00 NDC: 70518-2192-01 NDC: 70518-2192-02 PACKAGING: 30 in 1 BLISTER PACK PACKAGING: 28 in 1 BLISTER PACK PACKAGING: 20 in 1 BLISTER PACK Store at 20° to 25°C (68° to 77°F) (see USP Controlled Room Temperature). Keep tightly closed. Dispense in a tight container, as defined in the USP. KEEP OUT OF THE REACH OF CHILDREN. Repackaged and Distributed By: Remedy Repack, Inc. 625 Kolter Dr. Suite #4 Indiana, PA 1-724-465-8762

Статус Оторизация:

Abbreviated New Drug Application

Данни за продукта

PENICILLIN V POTASIUM- PENICILLIN V POTASIUM TABLET
REMEDYREPACK INC.
----------
PENICILLIN-VK
PENICILLIN V POTASSIUM TABLETS, USP
250 MG (400,000 UNITS)
500 MG (800,000 UNITS)
RX ONLY
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of
penicillin-VK and other antibacterial drugs, penicillin-VK should be
used only to treat or
prevent infections that are proven or strongly suspected to be caused
by bacteria.
DESCRIPTION
Penicillin V is the phenoxymethyl analog of penicillin G.
Penicillin V potassium is the potassium salt of penicillin V.
MOLECULAR FORMULA: C
H
O
KN
S
MOLECULAR WEIGHT: 388.5
Penicillin -VK (Penicillin V Potassium Tablets USP), for oral
administration, contain 250 mg
(400,000 units) or 500 mg (800,000 units) penicillin V. In addition,
each tablet contains
the following inactive ingredients: hydroxypropyl methylcellulose,
magnesium stearate,
polyethylene glycol, povidone, talc, and titanium dioxide.
CLINICAL PHARMACOLOGY
Penicillin V exerts a bactericidal action against penicillin-sensitive
microorganisms during
the stage of active multiplication. It acts through the inhibition of
biosynthesis of cell-wall
mucopeptide. It is not active against the penicillinase-producing
bacteria, which include
many strains of _staphylococci_. The drug exerts high _in vitro_
activity against
_staphylococci_ (except penicillinase-producing strains),
_streptococci_ (groups A, C, G, H, L
16
17
5
2
and M), and _pneumococci_. Other organisms sensitive _in vitro_ to
penicillin V are
_Corynebacterium diphtheriae, Bacillus anthracis, Clostridia,
Actinomyces bovis,_
_Streptobacillus moniliformis, Listeria monocytogenes, Leptospira, and
Neisseria_
_gonorrhoeae. Treponema pallidum_ is extremely sensitive.
The potassium salt of penicillin V has the distinct advantage over
penicillin G in resistance
to inactivation by gastric acid. It may be given with meals; however,
blood levels are
slightly higher when the drug is given on an empty stomach. Average
blood levels are
two to five times higher th