Paxtine

Страна: Австралия

Език: английски

Източник: Department of Health (Therapeutic Goods Administration)

Активна съставка:

Paroxetine hydrochloride hemihydrate

Предлага се от:

Alphapharm Pty Ltd

Клас:

Medicine Registered

Листовка

PAXTINE

_contains the active ingredient paroxetine (hydrochloride)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Paxtine.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Paxtine against
the benefits expected for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT IS PAXTINE USED
FOR
Paxtine is used to treat:
•
major depression and prevent the
return of depressive symptoms
•
obsessive compulsive disorder
(OCD) and prevent its recurrence
•
panic disorders (panic attacks)
and prevent its recurrence
•
social anxiety disorder/social
phobia
•
general anxiety disorder (GAD)
•
post-traumatic stress disorder
(PTSD).
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY PAXTINE HAS
BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed
Paxtine for another reason.
Paxtine is available only with a
doctor's prescription.
Paxtine belongs to a group of
medicines called selective serotonin
reuptake inhibitors (SSRIs). SSRIs
are thought to work by acting on
chemicals in the brain called amines,
which are involved in controlling
mood.
Paxtine corrects this chemical
imbalance and helps to relieve the
symptoms of the above conditions.
Depression is a disorder where 'low
moods' or feelings of sadness last
longer, or are more severe than those
that everyone has from time to time.
Depression is thought to be caused
by a chemical imbalance in certain
parts of the brain.
This imbalance affects your whole
body and can cause emotional and
physical symptoms such as low
spirit, loss of interest in usual
activities, changes in appetite, trouble
sleeping, low energy and feeling
guilty for no reason.
Obsessive compulsive disorder
(OCD) is a condition where a person
may have an irrational fear

Данни за продукта

PAXTINE 
_Paroxetine hydrochloride hemihydrate _
PRODUCT INFORMATION

NAME OF THE MEDICINE 
PAXTINE (paroxetine hydrochloride hemihydrate) is an
orally administered antidepressant with a chemical 
structure unrelated to other selective serotonin reuptake
inhibitors or to tricyclic, tetracyclic or other available 
antidepressant
agents.  It is the hydrochloride salt of a phenylpiperidine compound identified
chemically as  
(-)-trans-4R-(4'-fluorophenyl)-3S
-
[(3',4'-methylenedioxyphenoxy)methyl]-piperidine hydrochloride 
hemihydrate.  The molecular
weight of paroxetine hydrochloride hemihydrate is 374.8 (329.4
as free base).  
The CAS Registry number for paroxetine (as free base) is 61869-08-7.  
F
O
O
O
CH
2
N
H
.HCl 
CAS Registry No.: 61869-08-7 
DESCRIPTION

Paroxetine hydrochloride is an odourless, off white
powder, with a melting point range of 120

C to 138

C and 
solubility of 5.4 mg/mL in water. 
Each  PAXTINE  tablet  contains  20  mg  of  paroxetine  (as  hydrochloride).    PAXTINE  tablets  also  contain 
titanium dioxide (white) as  colourant, calcium hydrogen phosphate, hypromellose, sodium starch glycollate, 
magnesium stearate, polysorbate 80, macrogol 400 and
titanium dioxide as excipients. 
PAXTINE tablets do not contain sucrose, lactose, gluten,
tartrazine or any other azo dyes. 
PHARMACOLOGY

Paroxetine  is  a  potent  and  selective  inhibitor  of  5-hydroxytryptamine  (5-HT,  serotonin)  uptake  and  its 
antidepressant  action  and  efficacy  in  the  treatment  of  Obsessive  Compulsive  Disorder  (OCD),  Panic 
Disorder,  Social  Anxiety  Disorder/Social  Phobia,  Generalised  Anxiety  Disorder  (GAD)  and  Post-traumatic 
Stress Disorder (PTSD) are thought to be related
to its specific inhibition of 5-HT uptake in brain neurones. 
_In vitro_ studie