MUCOXIN TABLET 8MG

Страна: Малайзия

Език: английски

Източник: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Активна съставка:

Bromhexine HCl

Предлага се от:

DUOPHARMA (M) SDN. BHD.

INN (Международно Name):

Bromhexine HCl

Броя в опаковка:

1000 Tablets

Произведено от:

DUOPHARMA (M) SDN. BHD.

Листовка

_Consumer Medication Information Leaflet (RIMUP)_
1
MUCOXIN TABLET 8MG
Bromhexine hydrochloride (8mg)
WHAT IS IN THE LEAFLET?
1. What MUCOXIN is used
for
2. How MUCOXIN works
3. Before you use MUCOXIN
4. How to use MUCOXIN
5. While you are using it
6. Side effects
7. Storage and Disposal of
MUCOXIN
8. Product Description
9. Manufacturer and Product
Registration
Holder
10.
Date of Revision
WHAT MUCOXIN IS USED FOR
MUCOXIN
is
used
in
conditions where there are a lot
of thick secretions or phlegm
in your air passages.
HOW MUCOXIN WORKS
MUCOXIN
contains
bromhexine hydrochloride as
an active ingredient.
Helps
to
clear
the
chest
by
thinning the phlegm in your air
passages.
If you are not sure whether you
should
start
taking
this
medicine, talk to your doctor.
-
_ Before you start to use it_
Tell
your doctor if
you have
allergies
to
any
other
medicines, foods, preservatives
or dyes.
Ask your doctor or pharmacist
for
advice
before
taking
this
medicine if you are pregnant or
breastfeeding.
Tell your doctor if you have:
- Liver problem
- Kidney problem
- Gastric ulcer
-
_ Taking other medicines_
Tell your doctor or pharmacist
if you are taking any other
medicines, including any that
you get without prescription
from your pharmacy,
supermarket or health food
shop.
avoid
while
taking
this
medicine.
HOW TO USE MUCOXIN
Follow all directions given to
you
by
your
doctor
and
pharmacist carefully.
These
directions
may
differ
from the information contained
in this leaflet.
If you do not understand the
instructions
on
the
pack,
ask
your doctor or pharmacist for
help.
-
_ How much to use_
Adult:
Initially, take two
tablets three
times a day for first seven days.
For maintenance, one tablet
three times a day.
Children over the age of three
years:
Take one tablet three times a
day.
BEFORE YOU USE MUCOXIN
-
_ When you must not take it_
Do not take this medicine if
you have an allergy to:
- bromhexine hydrochloride
- any of the other ingredients
listed
at
the
end
of
this
leaflet
Do not take this medicine after
the expiry date printed on

Данни за продукта

[DUOPHARMA (M) SDN BHD]
[Page 1/2]
_ _
(Revision Date: 26.03.2019)
MUCOXIN
DESCRIPTION:
MUCOXIN ELIXIR 4 MG/ ML: A clear, green syrup.
MUCOXIN TABLET 8 MG: A round scored tablet, blue in colour, 7 mm
diameter with marking ‘duo’
COMPOSITION:
MUCOXIN ELIXIR 4 MG/ ML: Each 5 ml syrup contains Bromhexine
Hydrochloride 4 mg. PRESERVATIVES: Methyl Paraben 0.1%; Propyl Paraben
0.033%
MUCOXIN TABLET 8 MG: Each tablet contains Bromhexine Hydrochloride 8
mg.
PHARMACODYNAMICS:
Bromhexine hydrochloride is a mucolytic. It has been shown to enhance
the transport of mucus by reducing its viscosity and by activating the
ciliated epithelium (mucociliary clearance).
Preclinical studies show that there is an increase in the amount of
thin watery bronchial secretion.
PHARMACOKINETICS:
Enteric absorption of bromhexine in man is relatively rapid, with an
absorption half-life of 0.4 hours. Peak blood levels are reached
within approximately 1 hour after oral administration.
Bromhexine undergoes extensive first-pass metabolism with at least ten
metabolites identified. Food eaten before administration of bromhexine
enhances bioavailability. Following oral
administration, bromhexine shows dose-linearity in the dose range 8-32
mg. There is a high level of protein binding and a large distribution
volume. Bromhexine accumulates in the lung
rather than in the plasma. The dominant elimination half-life is 1
hour; the terminal elimination half-life is 13-40 hours. Following
oral administration of 8 mg, the plasma levels fell after 8-12
hours to 1.5 ng/mL and 0.2 ng/mL, respectively. For the most part,
bromhexine is excreted in the urine as metabolites that pass through
the kidneys while only minor amounts of parent
compound are found in unchanged form in the urine. After 24 hours and
5 days, 70 and 88% of the oral dose respectively is recovered in the
urine, 4% is excreted with the faeces.
Bromhexine does not accumulate, as the long terminal elimination
half-life is not dominant. Steady state levels are reached after three
days at the latest