Страна: Армения
Език: английски
Източник: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
lidocaine (lidocaine hydrochloride), epinephrine
Liqvor CJSC
N01BB52
lidocaine (lidocaine hydrochloride), epinephrine
20mg/ml+ 0,01mg/ml
solution for injection
(1) and (10) glass vial 20ml
Prescription
Registered
2019-02-08
INSTRUCTIONS FOR MEDICAL USE LIDOCAINE-LIQVO WITH EPINEPHRINE 1 % and 2 % solution for injection REGISTRATION NUMBER: __________________ TRADE NAME: Lidocaine-Liqvo with epinephrine INTERNATIONAL NONPROPRIETARY NAME: Lidocaine, Epinephrine. PHARMACEUTICAL FORM: Solution for injection. STRENGTH: 1 % and 2 % with epinephrine 1:100000 COMPOSITION: _ active ingredients_: lidocaine hydrochloride – 10.0 mg or 20.0 mg, epinephrine hydrotartrate equivalent to epinephrine – 0.01 mg; _inactive ingredients_: sodium chloride – 7.0 mg, sodium metabisulfite – 0.5 mg, citric acid – 0.2 mg, benzalkonium chloride – 0.05 mg, water for injection – up to 1.0 ml. DESCRIPTION: Clear, colorless or slightly yellowish solution. PHARMACOTHERAPEUTICAL GROUP: Local anesthetic. CODE ATC: N01BB52 PHARMACOLOGICAL EFFECT _PHARMACODYNAMICS _ Lidocaine is a local anaesthetic of the amide type. It causes all types of local anesthesia: terminal, infiltration, conduction. The local anesthetic action consists in neuronal membrane stabilization by reducing its penetration for sodium ions, which prevents action potential occurrence and impulse conduction. It rapidly hydrolyzes in a slightly alkaline media of tissues and after a short latent period acts within 60-90 minutes. Anesthetic activity decreases with tissue acidosis. Epinephrine - adrenoceptor agonist, constricts blood vessels and prolongs lidocaine action. _PHARMACOKINETICS _ Lidocaine is readily absorbed from the gastrointestinal tract, from mucous membranes and through damaged skin also in case of intramuscular administration. The elimination half-life is 2 hours. Lidocaine is metabolized in liver with formation of two pharmacologically active metabolites. It_ _ eliminates with urine: approximately 90% of dose is excreted in the form of metabolites and less than 10% - unchanged. Lidocaine crosses the blood-brain and placental barriers. _ _ _ _ INDICATIONS FOR USE All types of local anesthesia (infiltration and conduction anesthesia, peripheral nerve blocks) in dentistry, ophtha Прочетете целия документ