Genoral

Страна: Австралия

Език: английски

Източник: Department of Health (Therapeutic Goods Administration)

Активна съставка:

Piperazine oestrone sulfate

Предлага се от:

Pfizer Australia Pty Ltd

Клас:

Medicine Registered

Листовка

GENORAL(R)
1
GENORAL(R)
_Piperazine oestrone sulfate_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
Please read this leaflet carefully
before taking GENORAL. This
leaflet answers some common
questions about GENORAL.  It does
not contain all the available
information and it does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits.  Your doctor has weighed
the risks of you taking this medicine
against the expected benefits it will
have for you.
Take GENORAL as instructed and
follow the advice given in this
leaflet.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT GENORAL IS
USED FOR
GENORAL belongs to a group of
medicines called oestrogens.
Oestrogens are female hormones
produced by the body and are
necessary for the sexual development
of the female and for the control of
the menstrual cycle during child
bearing years.
GENORAL is used to treat one or
more of the following:
*
to provide additional hormone
when the body does not produce
enough of its own
*
to manage signs of menopause
such as hot flashes, itching,
burning or dryness in or around
the vagina.
Other hormones called progestogens
may be prescribed at the same time as
GENORAL.  This is known as
Hormone Replacement Therapy or
HRT.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another reason.
This medicine is only available with
a doctor's prescription.
BEFORE YOU TAKE
GENORAL
See your doctor for a physical
examination before you start to take
GENORAL.  In deciding to give you
GENORAL, your doctor has
weighed the benefits of taking
GENORAL against the possible side
effects and risks.
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE GENORAL IF:
*
you are allergic to GENORAL,
any other oestrogen o

Данни за продукта

PRODUCT INFORMATION 
GENORAL
®
 TABLETS 
NAME OF DRUG 
Non-proprietary name:  piperazine oestrone sulfate 
Chemical name:  oestra-1,3,5(10)-trien-17-one,3-(sulphoxy) compounded
with piperazine 
(1:1) 
CAS No: [7280-37-7] 
DESCRIPTION 
GENORAL (piperazine oestrone sulfate) is an oestrogenic substance
prepared from purified 
crystalline oestrone, solubilised as the sulfate and stabilised with
piperazine.  It is appreciably 
soluble in water and has almost no odour or taste.  The amount of
piperazine in GENORAL is 
not sufficient to exert a pharmacological action.  Its addition
ensures solubility, stability and 
uniform potency of the oestrone sulfate.  The structural formula is
shown below: 
H
H
N
N
H
H
H
HO
O
O
S O
O
C
3
H

In addition to piperazine oestrone sulfate, these tablets also contain
lactose anhydrous, lactose 
monohydrate, hydroxypropylcellulose, cellulose microcrystalline,
potassium phosphate, 
trometamol, sodium starch glycollate, silica colloidal anhydrous,
magnesium stearate, 
vegetable oil and sunset yellow/quinoline yellow dyes. 
PHARMACOLOGY 
The active component, oestrone, is presented as piperazine oestrone
sulfate, an oestrogenic 
substance.  Oestrogen drug products act by regulating the
transcription of a limited number of 
genes.  Oestrogens diffuse through the cell membranes, distribute
themselves throughout the 
cell and bind to and activate the nuclear oestrogen receptor, a DNA
binding protein which is 
found in oestrogen-responsive tissues.  The activated oestrogen
receptor binds to specific 
DNA sequences, or hormone-response elements, which enhance the
transcription of adjacent 
genes and in turn lead to the observed effects.  Oestrogen receptors
have been identified in 
tissues of the reproductive tract, breast, pituitary, hypothalamus,
liver, and bone of women. 
Endogenous oestrogens are known to cause growth stimulation and
maintain mature sexual 
development of the ovaries, the uterus and cervix, the vagina, the
fallopian tube