Dyna Clobetasol Cream 0.05%

Страна: Малайзия

Език: английски

Източник: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Активна съставка:

CLOBETASOL PROPIONATE

Предлага се от:

DYNAPHARM (M) SDN BHD

INN (Международно Name):

CLOBETASOL PROPIONATE

Броя в опаковка:

15 gm mcg/mL

Произведено от:

DYNAPHARM (M) SDN BHD

Листовка

Consumer Medication Information Leaflet (RiMUP)
DYNA CLOBETASOL CREAM 0.05%
Clobetasol Propionate (0.05% w/w)
1
What is in this leaflet
1.
What Dyna Clobetasol Cream 0.05%
is used for
2.
How Dyna Clobetasol Cream 0.05%
works
3.
Before you use Dyna Clobetasol
Cream 0.05%
4.
How to use Dyna Clobetasol Cream
0.05%
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Dyna
Clobetasol Cream 0.05%
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
What Dyna Clobetasol Cream 0.05%
is used for
Treatment of more resistant skin
conditions, such as psoriasis
(autoimmune condition that causes the
rapid buildup of skin cells), eczemas,
lichen planus, discoid lupus
erythematosus and other conditions
which do not respond satisfactorily to
less active steroids.
How Dyna Clobetasol Cream 0.05%
works
Corticosteroids give anti-inflammatory
effects to topical application.
Before you use Dyna Clobetasol
Cream 0.05%
-
When you must not use it
Do
not
use
Dyna
Clobetasol
Cream
0.05% if:
-
You have facial redness
-
You have acne and bumps around the
mouth.
-
Skin inflammation in children under 1
year, including napkin eruptions.
-
Skin lesions caused by infection with
viruses (such as herpes simplex,
chickenpox), fungi (such as
candidiasis, tinea) or bacteria (such as
impetigo (skin infection that mainly
affects infants and children)).
-
Hypersensitivity to Clobetasol or other
ingredients in the preparation.
Pregnancy and lactation
Do not take Dyna Clobetasol Cream
0.05% if you are pregnant, trying to get
pregnant or think you may be pregnant.
Do not take Dyna Clobetasol Cream
0.05% if you are breast-feeding. Ask
your doctor or pharmacist for advice
before taking any medicine.
- Before you start use it
-
Long term continuous therapy with
corticosteroid preparations should be
avoided, particularly in infants and
children, in whom adrenal suppression
occurs readily.
-
If corticosteroid preparations are
required for use in children, it is
recommended that the treatment should
be review

Данни за продукта

DYNA CLOBETASOL CREAM 0.05%
MAL19961875AZ
DESCRIPTION:
CREAM
Colour
:
White
Fragrance
:
Natural
CONTENT:
Clobetasol Propionate
......................................................... 0.05% w/w
Preservative: Chlorocresol
.................................................... 0.1% w/w
PHARMACODYNAMICS:
Corticosteroids diffuse across cell membranes and complex with
specific cytoplasmic receptors. These complexes then enter the cell
nucleus, bind
to DNA and stimulate transcription of messenger RNA (mRNA) and
subsequent protein synthesis of various enzymes thought to be
ultimately
responsible for anti-inflammatory effects to topical application of
corticosteroid.
PHARMACOKINETICS:
Corticosteroids when applied topically, particularly under an
occlusive dressing or when the skin is broken, sufficient
corticosteroid may be absorbed
to give systemic effects. Corticosteroids in the circulation are
extensively bound to plasma proteins, mainly to globulin and less so
to albumin. The
corticosteroid-binding globulin has high affinity but low binding
capacity, which the albumin has low affinity but large binding
capacity. Only unbound
corticosteroid has pharmacological effects or is metabolised. The
synthetic corticosteroids are less extensively protein bound than
hydrocortisone
(cortisol). They also tend to have longer half-lives. Corticosteroids
are metabolised mainly in the liver but also in the kidney, and are
excreted in the
urine. The slower metabolism of the synthetic corticosteroids with
their lower protein-binding affinity may account for their increased
potency
compared with the natural corticosteroids.
INDICATIONS:
Treatment of more resistant dermatoses, eg psoriasis, recalcitrant
eczemas, lichen planus, discoid lupus erythematosus and other
conditions which
do not respond satisfactorily to less active steroids.
RECOMMENDED DOSE:
Apply sparingly to the affected area once or twice daily until
improvement occurs. As with other highly active topical steroid
preparations, therapy
should be discontinued when control is ac