Страна: Сингапур
Език: английски
Източник: HSA (Health Sciences Authority)
Etamsylate
VIFOR PHARMA ASIA PACIFIC PTE. LTD.
B02BX01
500mg
CAPSULE
ORAL
Prescription Only
OM Pharma S.A.
2012-03-15
Dicynone ® 500 ANTIHAEMORRHAGIC COMPOSITION Active principle: Etamsylate Etamsylate 500 mg. Excipients q.s.f. 1 capsule PROPERTIES/EFFECTS Etamsylate is a synthetic antihaemorrhagic and an- gioprotective drug acting on the first step of hae- mostasis (endothelium-platelet interaction). By improving platelet adhesiveness and restoring cap- illary resistance, it is able to reduce bleeding time and blood losses. Etamsylate has no vasoconstrictor action; it does not influence fibrinolysis nor modify the plasma co- agulation factors. PHARMACOKINETICS When given p.o., etamsylate is slowly absorbed from the gastrointestinal tract. After oral administra- tion of 500 mg etamsylate maximum plasma level, i.e. 15 μg/ml, is reached at 4 h, but bioavailability is not known. The binding rate to plasma proteins is about 95%. Plasma half-life is about 3,7 h. About 72% of the administered dose are excreted in the first 24 h-urine; the molecule is excreted unchanged. Etamsylate crosses the placental barrier. Maternal and cord blood contain similar concentrations of et- amsylate. It is not known if etamsylate is excreted in the maternal milk. KINETICS IN PARTICULAR SITUATIONS It is not known if the pharmacokinetic properties of etamsylate are modified in patients suffering from renal and/or hepatic function disorders. INDICATIONS AND USAGE Dicynone ® 500 is a synthetic non-hormonal agent, used orally to reduce excessive capillary blood loss. Dicynone ® 500 acts principally by maintaining capil- lary integrity probably by promoting polymerisation of mucopolysaccharide in vessel walls. Following systemic administration of Dicynone ® 500, the mean bleeding time is significantly re- duced without any effect on cell counts, fibrinolysis, plasma protein levels, prothrombin time or clotting time. Dicynone ® 500 does not have a vasoconstricting ac- tion nor does it have any effect on hepatic or renal function. Dicynone ® 500 is used clinicall Прочетете целия документ