CARPROFEN tablet, chewable

Страна: САЩ

Език: английски

Източник: NLM (National Library of Medicine)

Активна съставка:

CARPROFEN (UNII: FFL0D546HO) (CARPROFEN - UNII:FFL0D546HO)

Предлага се от:

ZYVET ANIMAL HEALTH INC.

Начин на приложение:

ORAL

Вид предписание :

PRESCRIPTION

Терапевтични показания:

Carprofen is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprofen should not be used in dogs exhibiting previous hypersensitivity to carprofen.

Каталог на резюме:

Carprofen chewable tablets are scored, and contain 25 mg, 75 mg or 100 mg of carprofen per tablet. Each tablet size is packaged in bottles containing 30, 60 or 180 tablets.

Статус Оторизация:

Abbreviated New Animal Drug Application

Данни за продукта

CARPROFEN- CARPROFEN TABLET, CHEWABLE
ZYVET ANIMAL HEALTH INC.
----------
CARPROFEN
CHEWABLE TABLETS
NON-STEROIDAL ANTI-INFLAMMATORY DRUG
FOR ORAL USE IN DOGS ONLY
CAUTION:
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION:
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the
propionic acid class
that includes ibuprofen, naproxen, and ketoprofen. Carprofen is the
nonproprietary
designation for a substituted carbazole,
6-chloro-α-methyl-9H-carbazole-2-acetic acid.
The empirical formula is C15H12ClNO2 and the molecular weight 273.72.
The chemical
structure of carprofen is:
Carprofen is a white, crystalline compound. It is freely soluble in
ethanol, but practically
insoluble in water at 25°C.
CLINICAL PHARMACOLOGY:
Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent
with characteristic
analgesic and antipyretic activity approximately equipotent to
indomethacin in animal
models.
The mechanism of action of carprofen, like that of other NSAIDs, is
believed to be
associated with the inhibition of cyclooxygenase activity. Two unique
cyclooxygenases
have been described in mammals.
The constitutive cyclooxygenase, COX-1, synthesizes
prostaglandins necessary for normal gastrointestinal and renal
function. The inducible
1
2
cyclooxygenase, COX-2, generates prostaglandins involved in
inflammation. Inhibition of
COX-1 is thought to be associated with gastrointestinal and renal
toxicity while inhibition
of COX-2 provides anti-inflammatory activity. The specificity of a
particular NSAID for
COX-2 versus COX-1 may vary from species to species.
In an _in vitro _study using
canine cell cultures, carprofen demonstrated selective inhibition of
COX-2 versus COX-
1.
Clinical relevance of these data has not been shown. Carprofen has
also been shown
to inhibit the release of several prostaglandins in two inflammatory
cell systems: rat
polymorphonuclear leukocytes (PMN) and human rheumatoid synovial
cells, indicating
inhibition of acute (PMN system) and chronic