Страна: Канада
Език: английски
Източник: Health Canada
MEPIVACAINE HYDROCHLORIDE
PFIZER CANADA ULC
N01BB03
MEPIVACAINE
20MG
SOLUTION
MEPIVACAINE HYDROCHLORIDE 20MG
INTRACAUDAL
20 ML
Ethical
LOCAL ANESTHETICS
Active ingredient group (AIG) number: 0100583002; AHFS:
APPROVED
2017-08-02
1 PRESCRIBING INFORMATION CARBOCAINE 1% 10 mg/mL, Mepivacaine Hydrochloride Injection, USP CARBOCAINE 2% 20 mg/mL, Mepivacaine Hydrochloride Injection, USP Local Anesthetic Pfizer Canada Inc. 17300 Trans-Canada Highway Kirkland, Québec H9J 2M5 DATE OF REVISION: August 2, 2017 Control Number: 204807 2 PRESCRIBING INFORMATION CARBOCAINE 1% 10 mg/mL, Mepivacaine Hydrochloride Injection, USP CARBOCAINE 2% 20 mg/mL, Mepivacaine Hydrochloride Injection, USP Local Anesthetic PHARMACOLOGY: Mepivacaine stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthesia. Its pharmacological properties are somewhat similar to those of lidocaine, which it resembles chemically. Its action is more rapid in onset and somewhat more prolonged than that of lidocaine. It has been employed for all types of infiltration and regional nerve block anesthesia. Onset of anesthesia is rapid, the time of onset for sensory block ranging from about 3 to 20 minutes depending upon such factors as the anesthetic technique, the type of block, the concentration of the solution and the individual patient. The degree of motor blockade produced is dependent on the concentration of the solution. The 1% concentration will block sensory and sympathetic conduction without loss of motor function and will be effective in small superficial nerve blocks. The 2% concentration of mepivacaine will produce complete sensory and motor block of any nerve group. The duration of anesthesia also varies depending upon the technique and type of block, the concentration and the individual. Mepivacaine will normally provide anesthesia which is adequate for 2 to 2½ hours of surgery. It has been reported that vasoconstrictors do not significantly prolong anesthesia with mepivacaine, but epinephrine (1:200 000) may be added to the mepivacaine solution to promote local hemostasis and to delay systemic absorption of the anesthetic. The drowsiness and lassitude seen with lidocaine have not been commonly noted wit Прочетете целия документ