BUTATABS E

Страна: САЩ

Език: английски

Източник: NLM (National Library of Medicine)

Активна съставка:

PHENYLBUTAZONE (UNII: GN5P7K3T8S) (PHENYLBUTAZONE - UNII:GN5P7K3T8S)

Предлага се от:

Butler Animal health Supply, LLC dba Covetrus North America

INN (Международно Name):

PHENYLBUTAZONE

Композиция:

PHENYLBUTAZONE 1 g

Начин на приложение:

ORAL

Вид предписание :

PRESCRIPTION

Терапевтични показания:

For Oral Use in Horses Only. Non-steroidal anti-inflammatory drug (NSAID) Phenylbutazone chemically is 4-butyl-1, 2-diphenyl-3, 5-pyrazolidinedione. It has the following structural formula: Phenylbutazone was first synthesized in 1948 and introduced into human medicine in 1949, Kuzell 1,2,3 , Payne 4 , Fleming 5 , and Denko 6 , demonstrated the clinical effectiveness of phenylbutazone in gout, gouty arthritis, acute arthritis, acute rheumatism and various other rheumatoid disorders in humans. Fabre 7 , Domenjoz 8 , Wilhelmi 9 , and Yourish 10 , have established the anti-rheumatic and anti-inflammatory activity of phenylbutazone. It is entirely unrelated to the steroid hormones. Toxicity of phenylbutazone has been investigated in rats and mice 11 , Ogilvie and Sutter 12 , have also made a study on the chronic toxicity of phenylbutazone in dogs. They have shown that dogs receiving 10 mg. and 100 mg. per Kg. body weight, per day for 90 days, maintain good appetites, excrete normal feces, gain weight and maintain

Статус Оторизация:

Abbreviated New Animal Drug Application

Данни за продукта

BUTATABS E- PHENYLBUTAZONE TABLET
BUTLER ANIMAL HEALTH SUPPLY, LLC DBA COVETRUS NORTH AMERICA
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BUTATABS E
PHENYLBUTAZONE BOLUSES
For Oral Use in Horses Only.
Non-steroidal anti-inflammatory drug (NSAID)
DESCRIPTION & PHARMACOLOGY:
Phenylbutazone chemically is 4-butyl-1, 2-diphenyl-3,
5-pyrazolidinedione. It has the following
structural formula:
Phenylbutazone was first synthesized in 1948 and introduced into human
medicine in 1949, Kuzell
,
Payne , Fleming , and Denko , demonstrated the clinical effectiveness
of phenylbutazone in gout, gouty
arthritis, acute arthritis, acute rheumatism and various other
rheumatoid disorders in humans. Fabre ,
Domenjoz , Wilhelmi
, and Yourish
, have established the anti-rheumatic and anti-inflammatory activity
of phenylbutazone. It is entirely unrelated to the steroid hormones.
Toxicity of phenylbutazone has been
investigated in rats and mice
, Ogilvie and Sutter
, have also made a study on the chronic toxicity of
phenylbutazone in dogs. They have shown that dogs receiving 10 mg. and
100 mg. per Kg. body weight,
per day for 90 days, maintain good appetites, excrete normal feces,
gain weight and maintain a normal
blood picture. They also report no abnormal macroscopic or microscopic
changes in sacrificed animals
which could have been attributed to the drug. Phenylbutazone has been
used by Camberos
in
thoroughbred horses. Favorable results were reported in cases of
traumatism, muscle rupture, strains
and inflammations of the third phalanx. Results were not as favorable
in the periodic treatment of osteo-
arthritis of medial and distal bones of the hock, arthritis of the
stifle and hip, arthrosis of the trapezious
muscles, and generalized arthritis. Sutter
reported a favorable response in chronic equine arthritis of
long duration, fair results in a severely bruised mare, and poor
results in two cases where the condition
was limited to the third phalanx.
INDICATIONS:
Phenylbutazone is for the relief of inflammatory conditons associated
withthe musculoskeletal system in
hors