Страна: Армения
Език: английски
Източник: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
acetylsalicylic acid, paracetamol, caffeine
Arpimed LLC
acetylsalicylic acid, paracetamol, caffeine
200mg+200mg+40mg
tablets
OTC
SUMMARY PRODUCT CHARACTERISTIC (SPC) ASCOPHEN-ARPI TABLETS BRAND NAME – Ascophen-Arpi COMBINATION OF WELL-KNOWN GENERICS – Acetylsalicylic acid / Paracetamol / Caffeine COMPOSITION Each tablet_ _contains: _ACTIVE INGREDIENTS: _acetylsalicylic acid – 200 mg, paracetamol – 200 mg, caffeine – 40 mg; _INACTIVE INGREDIENTS:_ citric acid, microcrystalline cellulose, povidone, maize starch, sodium starch glycolate, magnesium stearate. PHARMACOLOGICAL GROUP AND ATC CODE Analgesic-antipyretic; N02BA51; N02BE51. PHARMACOLOGY ASCOPHEN-ARPI is the combined drug, which contains paracetamol, acetylsalicylic acid and caffeine. Acetylsalicylic acid and Paracetamol act as inhibitors of the enzyme cyclo-oxygenase, which results in the direct inhibition of the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. Caffeine is a methylxanthine, which inhibits the enzyme phosphodiesterase and has an antagonistic effect at central adenosine receptors. It may stimulate the respiratory center, increasing the rate and depth of respiration. Caffeine affects the tone of the cerebral vessels, but also enhances this combination of acetylsalicylic acid and paracetamol. The maximum effect of the drug develops within 10-60 minutes. PHARMACOKINETICS _ACETYLSALICYLIC ACID _ Acetylsalicylic acid and other salicylates are absorbed rapidly from the gastrointestinal tract when taken orally but absorption following rectal administration is less reliable. Acetylsalicylic acid and other salicylates can also be absorbed through the skin. After oral doses, absorption of non-ionised acetylsalicylic acid occurs in the stomach and intestine. Some acetylsalicylic acid is hydrolysed to salicylate in the gut wall. Once absorbed acetylsalicylic acid is rapidly converted to salicylate but during the first 20 minutes after a dose by mouth, acetylsalicylic acid is the predominant form of the drug in the plasma. Acetylsalicylic acid is 80 to 90% bound to plasma proteins and is widely distributed; its volume of distribution is reported to be Прочетете целия документ