Страна: САЩ
Език: английски
Източник: NLM (National Library of Medicine)
ADENOSINE (UNII: K72T3FS567) (ADENOSINE - UNII:K72T3FS567)
Baxter Healthcare Corporation
ADENOSINE
ADENOSINE 3 mg in 1 mL
PRESCRIPTION DRUG
Abbreviated New Drug Application
ADENOSINE- ADENOSINE INJECTION, SOLUTION BAXTER HEALTHCARE CORPORATION ---------- ADENOSINE INJECTION FOR RAPID BOLUS INTRAVENOUS USE RX ONLY DESCRIPTION Adenosine is an endogenous nucleoside occurring in all cells of the body. It is chemically 6-amino-9- ß-D-ribofuranosyl-9-H-purine and has the following structural formula: C H N O 267.24 Adenosine is a white crystalline powder. It is soluble in water and practically insoluble in alcohol. Solubility increases by warming and lowering the pH. Adenosine is not chemically related to other antiarrhythmic drugs. Adenosine injection is a sterile, nonpyrogenic solution for rapid bolus intravenous injection. Each mL contains 3 mg adenosine and 9 mg sodium chloride in Water for Injection. The pH of the solution is between 4.5 and 7.5. CLINICAL PHARMACOLOGY MECHANISM OF ACTION Adenosine slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome. Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline, and potentiated by blockers of nucleoside transport such as dipyridamole. Adenosine is not blocked by atropine. HEMODYNAMICS The intravenous bolus dose of 6 or 12 mg adenosine usually has no systemic hemodynamic effects. When larger doses are given by infusion, adenosine decreases blood pressure by decreasing peripheral resistance. PHARMACOKINETICS Intravenously administered adenosine is rapidly cleared from the circulation via cellular uptake, primarily by erythrocytes and vascular endothelial cells. This process involves a specific transmembrane nucleoside carrier system that is reversible, nonconcentrative, and bidirectionally symmetrical. Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase, or via deamination to inosine by adenosine deaminase in the cytosol. Since ad Прочетете целия документ