VERAPAMIL HYDROCHLORIDE tablet

البلد: الولايات المتحدة

اللغة: الإنجليزية

المصدر: NLM (National Library of Medicine)

العنصر النشط:

VERAPAMIL HYDROCHLORIDE (UNII: V3888OEY5R) (VERAPAMIL - UNII:CJ0O37KU29)

متاح من:

NuCare Pharmaceuticals, Inc.

INN (الاسم الدولي):

VERAPAMIL HYDROCHLORIDE

تركيب:

VERAPAMIL HYDROCHLORIDE 120 mg

طريقة التعاطي:

ORAL

نوع الوصفة الطبية :

PRESCRIPTION DRUG

الخصائص العلاجية:

Verapamil hydrochloride tablets USP are indicated for the treatment of the following: Angina 1.Angina at rest including:     -Vasospastic (Prinzmetal's variant) angina     -Unstable (crescendo, pre-infarction) angina 2.Chronic stable angina (classic effort-associated angina) Arrhythmias 1.In association with digitalis for the control of ventricular rate at rest and during stress in patients with chronic atrial flutter and/or atrial fibrillation (see WARNINGS: Accessory bypass tract ) 2.Prophylaxis of repetitive paroxysmal supraventricular tachycardia Essential hypertension Verapamil hydrochloride is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including this drug. Control of high blood pressure should be p

ملخص المنتج:

Verapamil Hydrochloride Tablets, USP 120 mg tablets are round, standard concave, white film-coated, scored, debossed "HP" above and "27" below on one side and plain on the reverse side, supplied as: NDC Number 66267-294-90 Bottle of 90 Store at 20° to 25°C (68° to 77°F) [See USP controlled room temperature] and protect from light. Dispense in a tight, light-resistant container using a child-resistant closure. MANUFACTURED FOR: Heritage Pharmaceuticals Inc. Eatontown, NJ 07724 1.866.901.DRUG (3784) 51U000000252US04 Issued: 09/16

الوضع إذن:

Abbreviated New Drug Application

خصائص المنتج

VERAPAMIL HYDROCHLORIDE- VERAPAMIL HYDROCHLORIDE TABLET
NUCARE PHARMACEUTICALS, INC.
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VERAPAMIL HYDROCHLORIDE TABLETS, USP 40 MG AND 120 MG
DESCRIPTION
Verapamil hydrochloride (verapamil HCl) is a calcium ion influx
inhibitor (slow-channel blocker or
calcium ion antagonist) available for oral administration in
film-coated tablets containing 40 mg, or 120
mg of verapamil hydrochloride.
The structural formula of verapamil HCl is:
C
H
N
O
• HCl M.W. = 491.08
Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]
methylamino]propyl]-3,4-dimethoxy-a-(1-
methylethyl) hydrochloride
Verapamil HCl is an almost white, crystalline powder, practically free
of odor, with a bitter taste. It is
soluble in water, chloroform, and methanol. Verapamil HCl is not
chemically related to other
cardioactive drugs.
Inactive ingredients include colloidal silicon dioxide, dibasic
calcium phosphate dihydrate, magnesium
stearate, microcrystalline cellulose, sodium starch glycolate, light
mineral oil, sodium lauryl sulfate,
titanium dioxide and hypromellose.
CLINICAL PHARMACOLOGY
Verapamil hydrochloride is a calcium ion influx inhibitor
(slow-channel blocker or calcium ion
antagonist) that exerts its pharmacologic effects by modulating the
influx of ionic calcium across the
cell membrane of the arterial smooth muscle as well as in conductile
and contractile myocardial cells.
MECHANISM OF ACTION
ANGINA: The precise mechanism of action of verapamil hydrochloride as
an antianginal agent remains to
be fully determined, but includes the following two mechanisms:
1. _Relaxation and prevention of coronary artery spasm:_ Verapamil
hydrochloride dilates the main
coronary arteries and coronary arterioles, both in normal and ischemic
regions, and is a potent inhibitor
of coronary artery spasm, whether spontaneous or ergonovine-induced.
This property increases
myocardial oxygen delivery in patients with coronary artery spasm and
is responsible for the
effectiveness of verapamil hydrochloride in vasospastic (Prinzmetal's
or variant) as well