VERAPAMIL HYDROCHLORIDE injection solution

البلد: الولايات المتحدة

اللغة: الإنجليزية

المصدر: NLM (National Library of Medicine)

العنصر النشط:

VERAPAMIL HYDROCHLORIDE (UNII: V3888OEY5R) (VERAPAMIL - UNII:CJ0O37KU29)

متاح من:

Cardinal Health

INN (الاسم الدولي):

VERAPAMIL HYDROCHLORIDE

تركيب:

VERAPAMIL HYDROCHLORIDE 2.5 mg in 1 mL

نوع الوصفة الطبية :

PRESCRIPTION DRUG

الوضع إذن:

Abbreviated New Drug Application

خصائص المنتج

VERAPAMIL HYDROCHLORIDE- VERAPAMIL HYDROCHLORIDE INJECTION, SOLUTION
CARDINAL HEALTH
----------
VERAPAMIL
HYDROCHLORIDE INJECTION, USP
ANSYR™ PLASTIC SYRINGE
AMPUL
FLIPTOP VIAL
Protect from light.
Rx only
DESCRIPTION
Verapamil hydrochloride is a calcium antagonist or slow-channel
inhibitor. Verapamil Hydrochloride
Injection, USP is a sterile, nonpyrogenic solution containing
verapamil hydrochloride 2.5 mg/mL and
sodium chloride 8.5 mg/mL in water for injection. The solution
contains no bacteriostat or antimicrobial
agent and is intended for single-dose intravenous administration. May
contain hydrochloric acid for pH
adjustment; pH is 4.9 (4.0 to 6.5).
The chemical name of Verapamil Hydrochloride, USP is
benzeneacetonitrile, α-[3-[{2-(3,4-
dimethoxyphenyl)ethyl} methylamino]
propyl]-3,4-dimethoxy-α-(1-methylethyl) hydrochloride.
Verapamil hydrochloride is a white or practically white crystalline
powder. It is practically odorless
and has a bitter taste. It is soluble in water; freely soluble in
chloroform; sparingly soluble in alcohol;
practically insoluble in ether. It has the following structural
formula:
Molecular weight: 491.07
Molecular formula: C
H N O • HCl
Verapamil hydrochloride is not chemically related to other
antiarrhythmic drugs.
The plastic syringe is molded from a specially formulated
polypropylene. Water permeates from inside
the container at an extremely slow rate which will have an
insignificant effect on solution concentration
over the expected shelf life. Solutions in contact with the plastic
container may leach out certain
chemical components from the plastic in very small amounts; however,
biological testing was
supportive of the safety of the syringe material.
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION: Verapamil inhibits the calcium ion (and possibly
sodium ion) influx through
slow channels into conductile and contractile myocardial cells and
vascular smooth muscle cells. The
antiarrhythmic effect of verapamil appears to be due to its effect on
the slow channel in cells of the
cardiac