RIFADIN rifampicin 600mg tablet blister

البلد: أستراليا

اللغة: الإنجليزية

المصدر: Department of Health (Therapeutic Goods Administration)

العنصر النشط:

Rifampicin

متاح من:

Sanofi-Aventis Australia Pty Ltd

INN (الاسم الدولي):

Rifampicin

خصائص المنتج

rifadin-ccdsv8-piv9-31jul17
_ _
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PRODUCT INFORMATION
RIFADIN
®
NAME OF THE MEDICINE
NON-PROPRIETARY NAME
rifampicin
CHEMICAL STRUCTURE
C
43
H
58
N
4
O
12
DESCRIPTION
Rifampicin is a semisynthetic antibiotic derivative of rifamycin B.
Specifically, rifampicin is the hydrazone,
3-(4-methylpiperazinyliminomethyl) rifamycin SV. It is only slightly
soluble in water and is rather unstable
to light and moisture.
Excipients present in the capsules are maize starch, magnesium
stearate, titanium dioxide, erythrosine,
indigo carmine and gelatin.
Excipients present in the tablets are sodium lauryl sulfate,
microcrystalline cellulose, lactose monohydrate,
calcium stearate, carmellose sodium, maize starch, magnesium stearate,
acacia, povidone, erythrosine,
titanium dioxide, sucrose, purified talc, magnesium carbonate hydrate,
kaolin, colloidal anhydrous silica and
gelatin.
Excipients present in the injection are sodium formaldehyde
sulfoxylate and sodium hydroxide, the diluent
is water for injections.
Excipients present in the syrup are agar, sucrose, methyl
hydroxybenzoate, propyl hydroxybenzoate,
potassium
sorbate,
saccharin,
sodium
metabisulfite,
polysorbate
80,
raspberry
essence
(PI
458),
diethanolamine and purified water.
PHARMACOLOGY
Rifampicin
is
particularly
active
against
rapidly
growing
extracellular
organisms
but
it
also
has
bactericidal
activity
intracellularly
and
against
slow
and
intermittently
growing
_Mycobacterium _
_tuberculosis. _
Rifampicin
inhibits
DNA
dependent
RNA
polymerase
activity
in
susceptible
cells.
Specifically, it interacts with bacterial RNA polymerase, but does not
inhibit the mammalian enzyme.
Cross resistance to rifampicin has only been shown with other
rifamycins.
PHARMACOKINETICS
Rifampicin is readily absorbed from the stomach and the duodenum. Peak
serum concentrations of the
order of 7 microgram/mL (range 6 to 32 microgram/mL) occur about 2 to
4 hours after an oral dose of
600 mg on an empty stomach.
In normal subjects the biological half-life of rifampicin in serum
averages about 3