PROBENECID tablet, film coated

البلد: الولايات المتحدة

اللغة: الإنجليزية

المصدر: NLM (National Library of Medicine)

العنصر النشط:

PROBENECID (UNII: PO572Z7917) (PROBENECID - UNII:PO572Z7917)

متاح من:

Medstone Pharma LLC

طريقة التعاطي:

ORAL

نوع الوصفة الطبية :

PRESCRIPTION DRUG

الخصائص العلاجية:

Probenecid tablets are indicated for the treatment of the hyperuricemia associated with gout and gouty arthritis. As an adjuvant to therapy with penicillin or with ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin, for elevation and prolongation of plasma levels by whatever route the antibiotic is given. Hypersensitivity to probenecid. Children under 2 years of age. Not recommended in persons with known blood dyscrasias or uric acid kidney stones. Therapy with probenecid should not be started until an acute gouty attack has subsided.

ملخص المنتج:

Probenecid Tablets, USP are available containing 500 mg of Probenecid, USP. The tablets are capsule shaped, film-coated yellow, debossed LCI on one side and 1367 on the other side. They are available as follows: NDC 0527-1367-01     bottles of 100 tablets NDC 0527-1367-10     bottles of 1000 tablets STORE AT 20° -25°C (68° -77°F) [See USP Controlled Room Temperature] PROTECT FROM LIGHT. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure. Distributed by: Lannett Company, Inc. Philadelphia, PA 19136 CIB70317B Rev 04/16

الوضع إذن:

Abbreviated New Drug Application

خصائص المنتج

PROBENECID- PROBENECID TABLET, FILM COATED
MEDSTONE PHARMA LLC
----------
PROBENECID TABLETS, USP
500 MG
RX ONLY
DESCRIPTION
Probenecid is a uricosuric and renal tubular transport blocking agent.
The chemical name for probenecid is 4-[(dipropylamino) sulfonyl]
benzoic acid. It has the
following structural formula:
Probenecid, USP is a white or nearly white, fine, crystalline powder.
Probenecid is soluble
in dilute alkali, in alcohol, in chloroform, and in acetone; it is
practically insoluble in water
and in dilute acids.
Each tablet for oral administration contains 500 mg of probenecid and
the following
inactive ingredients: microcrystalline cellulose, sodium lauryl
sulfate, sodium starch
glycolate, starch (corn), povidone, colloidal silicon dioxide,
magnesium stearate, polyvinyl
alcohol, titanium dioxide, polyethylene glycol, talc, D&C Yellow #10
Aluminum Lake, FD&C
Yellow #6 Aluminum Lake, and FD&C Blue #2 Aluminum Lake.
CLINICAL PHARMACOLOGY
Probenecid is a uricosuric and renal tubular blocking agent. It
inhibits the tubular
reabsorption of urate, thus increasing the urinary excretion of uric
acid and decreasing
serum urate levels. Effective uricosuria reduces the miscible urate
pool, retards urate
deposition, and promotes resorption of urate deposits.
Probenecid inhibits the tubular secretion of penicillin and usually
increases penicillin
plasma levels by any route the antibiotic is given. A 2-fold to 4-fold
elevation has been
demonstrated for various penicillins.
Probenecid also has been reported to inhibit the renal transport of
many other
compounds including aminohippuric acid (PAH), aminosalicylic acid
(PAS), indomethacin,
sodium iodomethamate and related iodinated organic acids,
17-ketosteroids,
pantothenic acid, phenolsulfonphthalein (PSP), sulfonamides, and
sulfonylureas. See also
Drug Interactions.
Probenecid decreases both hepatic and renal excretion of
sulfobromophtalein (BSP). The
tubular reabsorption of phosphorus is inhibited in hypoparathyroid but
not in
euparathyroid individuals.
Probenecid doe