البلد: المملكة المتحدة
اللغة: الإنجليزية
المصدر: VMD (Veterinary Medicines Directorate)
Clostridium perfringens, Escherichia coli
MSD Animal Health UK Limited
QI09AB08
Clostridium perfringens, Escherichia coli
Suspension for injection
POM-V - Prescription Only Medicine – Veterinarian
Pigs
Inactivated Bacterial Vaccine
Authorized
2012-06-14
Issued: April 2022 AN: 02836/2021 Page 1 of 5 SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Porcilis ColiClos suspension for injection for pigs 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each dose of 2 ml contains: ACTIVE SUBSTANCES: _Escherichia coli _components: - F4ab fimbrial adhesin 9.7 log 2 Ab titre 1 - F4ac fimbrial adhesin 8.1 log 2 Ab titre 1 - F5 fimbrial adhesin 8.4 log 2 Ab titre 1 - F6 fimbrial adhesin 7.8 log 2 Ab titre 1 - LT toxoid 10.9 log 2 Ab titre 1 _Clostridium perfringens_ component: - Type C (strain 578) beta toxoid ≥20 IU 2 1 Mean antibody titre (Ab) obtained after vaccination of mice with a 1/20 or 1/40 sow dose 2 International units of beta antitoxin according to Ph. Eur. ADJUVANT: dl- -tocopheryl acetate 150 mg For the full list of excipients, see section 6.1 3. PHARMACEUTICAL FORM Suspension for injection. Aqueous, white to nearly white. 4. CLINICAL PARTICULARS 4.1 TARGET SPECIES Pigs (sows and gilts) 4.2 INDICATIONS FOR USE, SPECIFYING THE TARGET SPECIES For the passive immunisation of progeny by active immunisation of sows and gilts to reduce mortality and clinical signs during the first days of life, caused by those _E. coli_ strains, which express the adhesins F4ab (K88ab), F4ac (K88ac), F5 (K99) or F6 (987P) and caused by _C. perfringens_ type C. Issued: April 2022 AN: 02836/2021 Page 2 of 5 4.3 CONTRAINDICATIONS None. 4.4 SPECIAL WARNINGS FOR EACH TARGET SPECIES Vaccinate healthy animals only. 4.5 SPECIAL PRECAUTIONS FOR USE Special precautions for use in animals Protection of piglets is achieved by colostrum intake. Therefore, care should be taken to ensure that each piglet ingests a sufficient quantity of colostrum. Special precautions to be taken by the person administering the veterinary medicinal product to animals In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician. 4.6 ADVERSE REACTIONS (FREQUENCY AND SERIOUSNESS) _In laboratory studies اقرأ الوثيقة كاملة