NEOTM SOLUBLE POWDER

البلد: ماليزيا

اللغة: الإنجليزية

المصدر: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

العنصر النشط:

NEOMYCIN SULPHATE; OXYTETRACYCLINE

متاح من:

Shennong Animal Health (Malaysia) Sdn. Bhd.

INN (الاسم الدولي):

NEOMYCIN SULPHATE; OXYTETRACYCLINE

الوحدات في الحزمة:

500 gm

المصنعة من قبل:

Shennong Animal Health (Malaysia) Sdn. Bhd.

خصائص المنتج

NEOTM
SOLUBLE POWDER
(FOR VETERINARY USE ONLY)
COMPOSITION
Neomycin (as sulfate)
…………………………….………………..…….................
200 mg/g
Oxytetracycline
…………………………………………………………………….……….
200 mg/g
PRODUCT DESCRIPTION
The finished product is light yellowish color powder.
TARGET SPECIES
Cattle (calves), sheep (lambs), swine and poultry.
PHARMACODYNAMIC
Neomycin is an antibiotic of the aminoglycoside obtained from
Streptomyces
fradiae.
Its
spectrum
of
activity includes
Grampositive, especially
staphylococci
and
less
active
streptococci,
and
Gram
negative,
especially Escherichia coli. Neomycin binds to the 30S subunit of the
bacterial
ribosome,
which
disturbs
the
reading
of the
constituent
code
of
the
messenger
RNA,
and
finally
the
bacterial
protein
synthesis.
At
high concentrations, it has been shown that aminoglycosides damage the
bacterial cell wall, adding bactericidal properties to bacteriostatic
properties.
Oxytetracycline binds reversibly to receptors of the 30S ribosomal
fraction,
this
leads
to
a
blocking
of
the
binding
of
aminoacyl-tRNA
to
the
corresponding site of the ribosome complex messenger-RNA. This results
in
inhibition of protein synthesis and therefore a growth arrest of the
bacterial
culture.
Oxytetracycline
is
a
bacteriostatic.
The
bacteriostatic
activity
of
oxytetracycline involves penetration of the substance into the
bacterial cell.
The penetration of oxytetracycline is exercised by both passive and
active
dissemination. The main possible resistance mode is related to the
presence
of
an
R
factor
responsible
for
a
decrease
in
active
transportation
oxytetracycline. Oxytetracycline is a broad spectrum antibiotic. It is
primarily
active
against
microorganisms
Gram
positive
and
negative,
aerobic
and
anaerobic, and against mycoplasma, Chlamydia and Rickettsiae. The
acquired
resistance to oxytetracycline was reported. Such resistance is usually
plasmid
origin.
Crossresistance
to
other
tetracyclines
is
possible.
Conti