البلد: المملكة المتحدة
اللغة: الإنجليزية
المصدر: MHRA (Medicines & Healthcare Products Regulatory Agency)
Magnesium sulfate heptahydrate
magnesium 2mmol/ml) solution for injection 10ml ampoules (Martindale Pharmaceuticals Ltd
B05XA05
Magnesium sulfate heptahydrate
500mg/1ml
Solution for injection
Intravenous; Intramuscular
No Controlled Drug Status
Valid as a prescribable product
BNF: 09050103; GTIN: 5026468000265
00000 WHAT IS IN THIS LEAFLET: 1. What Magnesium Sulfate Injection is and what it is used for 2. What you need to know before you are given Magnesium Sulfate Injection. 3. How Magnesium Sulfate Injection will be given 4. Possible side effects 5. How to store Magnesium Sulfate Injection 6. Contents of the pack and other information 1. WHAT MAGNESIUM SULFATE INJECTION IS AND WHAT IT IS USED FOR Magnesium Sulfate Injection is used to treat low levels of magnesium in the blood where it is not possible for the medicine to be taken by mouth. It may also be used to prevent seizures (fits) caused by a serious complication of pregnancy known as eclampsia. It is used in the treatment of acute hypomagnesaemia. 2. WHAT YOU NEED TO KNOW BEFORE YOU ARE GIVEN MAGNESIUM SULFATE INJECTION YOU SHOULD NOT BE GIVEN MAGNESIUM SULFATE INJECTION IF: · you are allergic to Magnesium Sulfate, its salts or any of the other ingredients of this medicine listed in section 6. · you suffer from severe kidney failure. WARNINGS AND PRECAUTIONS Talk to your doctor, pharmacist or nurse before receiving Magnesium Sulfate if you: • suffer from any kidney problem. • suffer from disease of the muscles causing drooping eyelids, double vision, difficulty in speaking and swallowing and sometimes muscle weakness in the arms or legs known as myasthenia gravis. DURING TREATMENT Your blood calcium levels will be routinely monitored whilst taking Magnesium Sulfate. OTHER MEDICINES AND MAGNESIUM SULFATE INJECTION Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription. Medicines which may interact with Magnesium Sulfate Injection include: • Digitalis glycosides e.g. digoxin (a medicine used to treat heart problems) • Barbiturates (e.g. amobarbital) • Opioids ( e.g. morphine) • Hypnotics ( e.g. nitrazepam) • Muscle relaxants e.g. tubocurarine • Calcium channel blockers e.g. nifedipine or nimodipine (medicines used to treat high blood pressure) w اقرأ الوثيقة كاملة
OBJECT 1 MAGNESIUM SULFATE 50%W/V SOLUTION FOR INJECTION Summary of Product Characteristics Updated 21-Feb-2018 | Martindale Pharma 1. Name of the medicinal product Magnesium Sulfate 50%w/v Solution for Injection 2. Qualitative and quantitative composition Magnesium Sulfate Heptahydrate 5g/ 10ml 2.5g/ 5ml 1g/ 2ml For full list of excipients, see section 6.1 3. Pharmaceutical form Sterile Solution for Injection A clear, colourless solution practically free from visible particles 4. Clinical particulars 4.1 Therapeutic indications • Treatment of Magnesium deficiency where the oral route of administration may be inappropriate.. • To prevent further seizures associated with eclampsia. 4.2 Posology and method of administration Dosage should be individualised according to patient's needs and responses. Plasma levels should also be monitored throughout therapy. _a) Treatment of magnesium deficiency in hypomagnesaemia:_ For intravenous administration, a concentration of 20% or less should be used; the rate of injection not exceeding 1.5ml/minute of a 10% solution or its equivalent. Up to 40g MgSO 4 (equivalent to 160mmol Mg 2+ ) by slow intravenous infusion (in glucose 5%) over up to 5 days, may be required to replace the deficit (allowing for urinary losses). Mild magnesium deficiency 1g intramuscularly every 6 hours for 4 doses. Severe magnesium deficiency Up to 250mg/kg intramuscularly given within a period of 4 hours or 5g/litre of infusion solution intravenously over 3 hours Paedriatric population It is recommended that the solution be diluted to 20% w/v prior to intramuscular injection Elderly No special recommendation except in renal impairment, see below Renal impairment: Dosage should be reduced in renal impairment. Plasma magnesium concentrations should be monitored throughout therapy _b) To prevent further seizures associated with eclampsia:_ An initial intravenous (IV) loading dose is followed for 24h by either an IV infusion, or regular intramuscular (IM) injections. _INTRAMUSCULAR MAINTENANCE REGIMEN_ A اقرأ الوثيقة كاملة