البلد: ماليزيا
اللغة: الإنجليزية
المصدر: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
LEVETIRACETAM
PAHANG PHARMACY SDN. BHD.
LEVETIRACETAM
30 Tablets; 100 Tablets
KUSUM HEALTHCARE PVT. LTD.
LOGUFEN LEVETIRACETAM TABLETS 250 MG & 500 MG 1 _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What Logufen is used for 2. How Logufen works 3. Before you use Logufen 4. How to use Logufen 5. While you are using it 6. Side effects 7. Storage and Disposal of Logufen 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision 11. Serial number 1. WHAT LOGUFEN IS USED FOR Logufen tablets contain a medicine called Levetiracetam. This belongs to a group of medicines called Antiepileptic medicine (a medicine used to treat seizures in epilepsy). Logufen is used: in adults and adolescents from 16 years of age with newly diagnosed epilepsy, to treat a certain form of epilepsy. Epilepsy is a condition where the patients have repeated fits (seizures). Levetiracetam is used for the epilepsy form in which the fits initially affect only one side of the brain, but could thereafter extend to larger areas on both sides of the brain (partial onset seizure with or without secondary generalisation). Levetiracetam has been given to you by your doctor to reduce the number of fits. as an add-on to other antiepileptic medicines to treat: partial onset seizures with or without generalisation in adults and children from 4 years of age myoclonic seizures (short, shock- like jerks of a muscle or group of muscles) in adults and adolescents from 12 years of age with juvenile myoclonic epilepsy; primary generalised tonic-clonic seizures (major fits, including loss of consciousness) in adults and adolescents from 12 years of age with idiopathic generalised epilepsy (the type of epilepsy that is thought to have a genetic cause). 2. HOW LOGUFEN WORKS Logufen is an antiepileptic medicine (a medicine used to treat seizures in epilepsy). 3. BEFORE YOU USE LOGUFEN - _When you must not use it_ If you are allergic (hypersensitive) to Levetiracetam or other pyrrolidone derivatives or to any of the excipients. (These are listed at the end of the leaflet). If you hav اقرأ الوثيقة كاملة
® LOGUFEN LEVETIRACETAM TABLETS 250 MG LEVETIRACETAM TABLETS 500 MG COMPOSITION: Each film-coated tablet contains: Levetiracetam BP………..250 mg/ 500 mg _EXCIPIENTS:_ ® LOGUFEN TABLETS 250 MG: Maize starch, povidone, croscarmellose sodium, colloidal anhydrous silica, magnesium stearate; Opadry (II) 85G68918 white. ® LOGUFEN TABLETS 500 MG: Maize starch, povidone, croscarmellose sodium, colloidal anhydrous silica, magnesium stearate; Opadry (II) 85G52482 yellow. PRODUCT DESCRIPTION: ® LOGUFEN TABLETS 250 MG: White to off white color, oval shape, film coated tablets, with break line on one side. ® LOGUFEN TABLETS 500 MG: Yellow color, oval shape, film coated tablets, with break line on one side. *The break line is non-functional and the scored tablet is not meant to be cut / split in half. PHARMACEUTICAL FORM: Film-coated tablet PHARMACOLOGICAL PROPERTIES: PHARMACOTHERAPEUTIC GROUP: Antiepileptics. Other antiepileptic. ATC code: N03AX14 PHARMACODYNAMIC PROPERTIES: ® Logufen contains Levetiracetam which is a pyrrolidone derivative (S-enantiomer of α-ethyl-2-oxo-1- pyrrolidineacetamide), chemically unrelated to existing antiepileptic active substances. The mechanism of action of levetiracetam still remains to be fully elucidated. Levetiracetam does not alter basic cell characteristics and normal neurotransmission. 2+ 2+ Levetiracetam affects intra-neuronal Ca levels by partial inhibition of N-type Ca currents and by reducing the 2+ release of Ca from intra-neuronal stores. In addition it partially reverses the reductions in GABA and glycine- gated currents induced by zinc and β-carbolines. Furthermore, levetiracetam bind to a specific site. This binding site is the synaptic vesicle protein 2A, believed to be involved in vesicle fusion and neurotransmitter exocytosis. Levetiracetam and related analogs show a rank order of affinity for binding to the synaptic vesicle protein 2A which correlates with the potency of their antiseizure protection. This suggests that the interaction between levetiracetam an اقرأ الوثيقة كاملة