البلد: أستراليا
اللغة: الإنجليزية
المصدر: Department of Health (Therapeutic Goods Administration)
Sodium thiosulfate
Hospira Australia Pty Ltd
Medicine Registered
DBL ™ Sodium Thiosulphate cmi Page 1 DBL™ SODIUM THIOSULPHATE INJECTION Sodium thiosulphate _ (SOE-dee-um thye-oh-SUL-fate)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about DBL ™ Sodium Thiosulphate Injection. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you being given sodium thiosulphate against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT BEING GIVEN THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET. You may need to read it again. WHAT DBL ™ SODIUM THIOSULPHATE INJECTION IS USED FOR This medicine is used: • in the emergency treatment of cyanide poisoning • to prevent cyanide poisoning when sodium nitroprusside is given. This medicine works by helping the body to convert cyanide to a less dangerous chemical called thiocyanate. _ _ ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is not addictive. BEFORE YOU ARE GIVEN DBL ™ SODIUM THIOSULPHATE INJECTION _BEFORE YOU ARE GIVEN IT _ TELL YOUR DOCTOR IF YOU HAVE AN ALLERGY TO: • any medicine containing sodium thiosulfate • any of the ingredients listed at the end of this leaflet • any other medicines, foods, preservatives or dyes. Some of the symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin. TELL YOUR DOCTOR IF YOU HAVE ANY OF THE FOLLOWING MEDICAL CONDITIONS: • high blood pressure • condi اقرأ الوثيقة كاملة
Product Information - Australia Version 4.0 Page 1 DBL ™ SODIUM THIOSULFATE INJECTION NAME OF THE MEDICINE Sodium thiosulfate DESCRIPTION The molecular formula of sodium thiosulfate is Na 2 S 2 O 3 .5H 2 O. It has a molecular weight of 248.2. The CAS registry number of sodium thiosulfate is 10102-17-7. DBL ™ Sodium Thiosulfate Injection is a clear, colourless, sterile solution. Each 10 mL vial contains 2.5 g of sodium thiosulfate (25% w/v solution). Each vial also contains 10.5 mg/mL sodium phosphate-dibasic dodecahydrate and 1.0 mg/mL sodium metabisulfite in water for injections. Sodium hydroxide and sulphuric acid are added as necessary to adjust the pH. The pH of the solution is between 7.0 and 9.0. PHARMACOLOGY Sodium thiosulfate is an antidote for cyanide poisoning. Cyanide poisoning can be rapidly fatal. When hydrogen cyanide gas is inhaled or large doses of cyanide are taken, toxicity occurs within a few seconds, and death occurs within minutes. The potentially lethal dose of potassium or sodium cyanide is 200 to 300 mg and of hydrocyanic acid is 50 mg. With smaller doses, toxicity occurs within minutes, and may include the following symptoms: constriction of the throat, nausea, vomiting, giddiness, headache, palpitations, hyperpnoea, then dyspnoea, bradycardia (which may be preceded by tachycardia), unconsciousness, violent convulsions followed by death. Sodium thiosulfate is generally used in conjunction with sodium nitrite in the treatment of cyanide poisoning. Cyanide has a high affinity for ferric ions, and reacts readily with the ferric ion of mitochondrial cytochrome oxidase. Sodium nitrite reacts with haemoglobin to form methaemoglobin, and cyanide preferentially binds to methaemoglobin, restoring cytochrome oxidase activity. As cyanide dissociates from methaemoglobin, it is converted to the relatively non-toxic thiocyanate by the enzyme rhodanese. اقرأ الوثيقة كاملة