CALCITRIOL capsules 0.5 mcg

البلد: الولايات المتحدة

اللغة: الإنجليزية

المصدر: NLM (National Library of Medicine)

العنصر النشط:

CALCITRIOL (UNII: FXC9231JVH) (CALCITRIOL - UNII:FXC9231JVH)

متاح من:

Bryant Ranch Prepack

INN (الاسم الدولي):

CALCITRIOL

تركيب:

CALCITRIOL 0.5 ug

نوع الوصفة الطبية :

PRESCRIPTION DRUG

الوضع إذن:

Abbreviated New Drug Application

خصائص المنتج

CALCITRIOL- CALCITRIOL CAPSULES 0.5 MCG CAPSULE
BRYANT RANCH PREPACK
----------
CALCITRIOL CAPSULES (0.25 MCG & 0.5 MCG)
RX ONLY
DESCRIPTION
Calcitriol is a synthetic vitamin D analog which is active in the
regulation of the absorption of calcium
from the gastrointestinal tract and its utilization in the body.
Calcitriol is available as capsules
containing 0.25 mcg or 0.5 mcg calcitriol All dosage forms contain
butylated hydroxyanisole (BHA)
and butylated hydroxytoluene (BHT) as antioxidants. The capsules
contain medium chain triglycerides.
Gelatin capsule shells contain glycerin, sorbitol, with the following
dye systems: 0.25-mcg FD&C
Yellow No. 6, FD&C red No.3 and titanium dioxide; 0.5 mcg- FD&C Yellow
No. 6, FD&C red No.3
and titanium dioxide. The imprinting ink contains propylene glycol,
shellac, black iron oxide, isopropyl
alcohol, N-butyl alcohol and ammonium hydroxide.
Calcitriol is a white, crystalline compound which occurs naturally in
humans. It has a calculated
molecular weight of 416.65 and is soluble in organic solvents but
relatively insoluble in water.
Chemically, calcitriol is 9, 10-seco(5Z,7E)-5,7,10(19)
cholestatriene-1α, 3β, 25-triol and has the
following structural formula:
CALCITRIOL
The other names frequently used for calcitriol are
lα,25-dihydroxycholecalciferol, 1, 25-
dihydroxyvitamin D , 1,25-DHCC, 1,25(OH) D and 1,25-diOHC.
CLINICAL PHARMACOLOGY
Man's natural supply of vitamin D depends mainly on exposure to the
ultraviolet rays of the sun for
conversion of 7-dehydrocholesterol in the skin to vitamin D
(cholecalciferol). Vitamin D must be
metabolically activated in the liver and the kidney before it is fully
active as a regulator of calcium and
phosphorus metabolism at target tissues. The initial transformation of
vitamin D is catalyzed by a
vitamin D -25-hydroxylase enzyme (25-OHase) present in the liver, and
the product of this reaction is
25-hydroxyvitamin D [25-(OH)D ]. Hydroxylation of 25-(OH)D occurs in
the mitochondria of kidney
tissue, activated by the renal 25-hydroxyvitami