Baxter Sevoflurane Inhalation Anesthetic Liquid 100%

البلد: ماليزيا

اللغة: الإنجليزية

المصدر: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

العنصر النشط:

SEVOFLURANE

متاح من:

BAXTER HEALTHCARE (MALAYSIA) SDN. BHD.

INN (الاسم الدولي):

SEVOFLURANE

الوحدات في الحزمة:

250ml mL

المصنعة من قبل:

BAXTER HEALTHCARE CORPORATION

خصائص المنتج

DESCRIPTION
Sevoflurane, USP, volatile liquid for inhalation, a nonflammable and
nonexplosive liquid
administered by vaporization, is a halogenated general inhalation
anesthetic drug.
Sevoflurane, USP is fluoromethyl 2,2,2,-trifluoro-1-(trifluoromethyl)
ethyl ether and its
structural formula is:
F
3
C
H
C
OCH
2
F
F
3
C
SEVOFLURANE, USP, PHYSICAL CONSTANTS ARE:
Molecular weight
200.05
Boiling point at 760 mm Hg
58.6°C
Specific gravity at 20°C
1.520 - 1.525
Vapor pressure in mm Hg
157 mm Hg at 20°C
197 mm Hg at 25°C
317 mm Hg at 36°C
DISTRIBUTION PARTITION COEFFICIENTS AT 37°C:
Blood/Gas
0.63 - 0.69
Water/Gas
0.36
Olive Oil/Gas
47 - 54
Brain/Gas
1.15
MEAN COMPONENT/GAS PARTITION COEFFICIENTS AT 25°C FOR POLYMERS USED
COMMONLY IN MEDICAL APPLICATIONS:
Conductive rubber
14.0
Butyl rubber
7.7
Polyvinylchloride
17.4
Polyethylene
1.3
Sevoflurane,
USP
is
nonflammable
and
nonexplosive
as
defined
by
the
requirements of International Electrotechnical Commission 601-2-13.
Sevoflurane, USP is a clear, colorless, liquid containing no
additives. Sevoflurane, USP
is not corrosive to stainless steel, brass, aluminum, nickel-plated
brass, chrome-plated
brass or copper beryllium. Sevoflurane, USP is nonpungent. It is
miscible with ethanol,
ether, chloroform, and benzene, and it is slightly soluble in water.
Sevoflurane, USP is
stable when stored under normal room lighting conditions according to
instructions. No
discernible degradation of sevoflurane, USP occurs in the presence of
strong acids or heat.
When in contact with alkaline CO
2
absorbents (e.g. Baralyme
®
and to a lesser extent soda
lime) within the anesthesia machine, Sevoflurane, USP can undergo
degradation under
certain conditions. Degradation of sevoflurane, USP is minimal, and
degradants are either
undetectable or present in non-toxic amounts when used as directed
with fresh absorbents.
Sevoflurane, USP degradation and subsequent degradant formation are
enhanced by
increasing absorbent temperature increased sevoflurane, USP
concentration, decreased
fresh gas f