APO-Imiquimod

البلد: أستراليا

اللغة: الإنجليزية

المصدر: Department of Health (Therapeutic Goods Administration)

العنصر النشط:

Imiquimod

متاح من:

Apotex Pty Ltd

الفئة:

Medicine Registered

نشرة المعلومات

APO-IMIQUIMOD

_Contains the active ingredient imiquimod_
CONSUMER MEDICINE INFORMATION

_FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about imiquimod. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
You can also download the most up
to date leaflet from
www.apotex.com.au.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is APO-
Imiquimod. It contains the active
ingredient imiquimod.
It is used to treat:
•
Solar keratosis on the face and
scalp.
 Solar keratosis is thickened, scaly
patches of skin caused by too
much sun exposure. It is also
known as actinic keratosis.
•
Basal cell carcinoma (a type of
skin cancer).
•
External genital/perianal warts
(condyloma acuminate). They
appear on the surface of the penis
or vulva (external female sexual
organ) and around the anus.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HOW IT WORKS_
Imiquimod is an immune response
modifier. It activates immune cells in
the body. The immune cells then
proceed to kill and remove the virus-
inf

خصائص المنتج

Product Information – Australia 
APO-Imiquimod Cream 
Page 1 
APO-IMIQUIMOD CREAM  

NAME OF THE MEDICINE 
Imiquimod. 

Chemical Name: 
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine  

Structural Formula: 

Molecular Formula: 
C
14
H
16
N
4

Molecular Weight: 
240.3 

CAS Registry Number:  99011-02-06 

DESCRIPTION 
Imiquimod is an odourless, white to
off-white crystalline solid.  

PHARMACOLOGY 
PHARMACODYNAMICS 
Imiquimod is an immune response modifier. Imiquimod has been shown
to stimulate the innate and 
adaptive immune response through the induction of interferon-
α (IFN-α) and other cytokine production by 
multiple cell types (e.g. macrophages; monocytes; B cells; plasmacytoid dendritic cells (pDC)). pDCs, a 
major subset of (pre-)DCs, have the highest expression
of Toll-like receptor7 (TLR7) amongst DC 
subsets. 

Imiquimod activates immune cells by engaging TLR7 and (to a lesser extent) Toll-like receptor-8 (TLR8) 
signalling, and consecutively, activation of nuclear factor-kappa
B (NF-
κB)  and  induction  of  pro-
inflammatory cytokines, chemokines and other mediators such as IFN-
α, tumour necrosis factor (TNF)α, 
interleukin (IL)-2, IL-6, IL-8, IL-12. 

Imiquimod induces an increase in markers for IFN-
γ  and  the  interferon  inducible  gene  product  2’5’-
oligoadenylate synthetase at the treatment site. 

Imiquimod has no direct in vitro antiviral activity. The
antiviral activity is indirect through cytokine induction 
of IFN-
α and immune activation. In addition, HPVL1 mRNA and HPV DNA are significantly decreased 
following treatment. However the clinical relevance
of these findings is unknown. 

As well as enhancing pro-inflammatory cytokine secretion
from pDCs, imiquimod enhances costimulatory 
marker expression, increase CCR7 (e.g. enabling migr