APO-FOSINOPRIL HCTZ

البلد: أستراليا

اللغة: الإنجليزية

المصدر: Department of Health (Therapeutic Goods Administration)

العنصر النشط:

Hydrochlorothiazide; Fosinopril sodium

متاح من:

Ranbaxy Australia Pty Ltd

الفئة:

Medicine Registered

نشرة المعلومات

 
APO-FOSINOPRIL HCTZ Tablets CMI V1 Apr 2008 

Page 1 of 13

APO-FOSINOPRIL HCTZ 10/12.5 MG AND APO-FOSINOPRIL HCTZ

20/12.5 MG  
_FOSINOPRIL + HYDROCHLOROTHIAZIDE TABLETS_ 
CONSUMER MEDICINE INFORMATION 
WHAT IS IN THIS LEAFLET  
This leaflet answers some common questions about APO-FOSINOPRIL
HCTZ 
10/12.5 MG and APO-FOSINOPRIL HCTZ 20/12.5 MG (fosinopril + 
hydrochlorothiazide tablets).  
It does not contain all the available information. 
It does not take the place of talking to your doctor
or pharmacist. 
All medicines have risks and benefits. Your doctor has weighed the
risks of you 
taking APO-FOSINOPRIL HCTZ 10/12.5 MG or APO-FOSINOPRIL HCTZ
20/12.5 MG 
against the benefits they expect it will have for you. 
IF YOU HAVE ANY CONCERNS ABOUT USING/TAKING THIS MEDICINE, ASK
YOUR DOCTOR 
OR PHARMACIST. 
KEEP THIS LEAFLET WITH THIS MEDICINE.  
You may need to read it again. 

WHAT APO-FOSINOPRIL HCTZ 10/12.5 MG AND APO-FOSINOPRIL HCTZ
20/12.5 
MG IS USED FOR 
APO-FOSINOPRIL HCTZ 10/12.5 MG and APO-FOSINOPRIL HCTZ 20/12.5
MG 
contain two medicines, fosinopril sodium and hydrochlorothiazide.
Both 
medicines reduce blood pressure, but work in
different ways. Fosinopril belongs 
to the class of medicines called Angiotensin Converting
Enzyme (ACE) inhibitors 
that act on the heart and blood vessels. Hydrochlorothiazide
is a diuretic, i.e., it 
works by making your kidneys pass more water and salt.
Together fosinopril and 
hydrochlorothiazide lower high blood pressure. 
Your doctor would have prescribed APO-FOSINOPRIL HCTZ 10/12.5
MG or APO-
FOSINOPRIL HCTZ 20/12.5 MG (fosinopril + hydrochlorothiazide
tablets)  for the 
following: 
  treatment of high blood pressure if treatment
of high blood pressure is not 
satisfactory with fosinopril alone.  
Fosinopril and hydrochlorothiazide tablets are
not suitable for initial therapy of 
high blood pressure.

خصائص المنتج

APO-FOSINOPRIL HCTZ PI V1 Aug 2008

Page 1 of 15

APO-FOSINOPRIL HCTZ 10/12.5 MG AND 20/12.5 MG TABLETS 

(FOSINOPRIL 10 MG + HYDROCHLOROTHIAZIDE 12.5 MG 
& 
FOSINOPRIL 20 MG + HYDROCHLOROTHIAZIDE 12.5 MG) 

NAME OF THE MEDICINE 

FOSINOPRIL + HYDROCHLOROTHIAZIDE TABLETS 10 + 12.5 MG 

Each tablet contains: 
Fosinopril sodium  

10 mg  
Hydrochlorothiazide Ph. Eur.  12.5 mg 

FOSINOPRIL + HYDROCHLOROTHIAZIDE TABLETS 20 + 12.5 MG 

Each tablet contains: 
Fosinopril sodium 

20 mg  
Hydrochlorothiazide Ph. Eur.  12.5 mg 

FOSINOPRIL SODIUM STRUCTURE 

CAS number 88889-14-9 

HYDROCHLOROTHIAZIDE STRUCTURE 

CAS Number: 58-93-5 

APO-FOSINOPRIL HCTZ PI V1 Aug 2008

Page 2 of 15

DESCRIPTION 

APO-FOSINOPRIL HCTZ 10/12.5 MG and APO-FOSINOPRIL HCTZ 20/12.5
MG TABLETS contain Fosinopril 
sodium and hydrochlorothiazide.  

Fosinopril sodium is the ester prodrug of a long-acting
angiotensin converting enzyme (ACE) inhibitor, 
fosinopril diacid. It is a sub-class of ACE inhibitors containing
a phosphinate group which makes it different 
from other marketed
ACE inhibitors. Fosinopril sodium is designated
chemically as: _L_-proline, 4-cyclohexyl-1- 
[[[2-methyl-1- (1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl]acetyl]-, sodium salt, _trans-_. The empiric 
formula of fosinopril sodium is C
30
H
45
NNaO
7
P. The molecular weight of fosinopril sodium is: 585.65. 
_Fosinopril sodium:  _

_Hydrochlorothiazide_
Hydrochlorothiazide is the 3,4-dihydro derivative of chlorothiazide
defined chemically as 6-chloro-3,4-dihydro-
2_H_-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide. The
empiric formula of hydrochlorothiazide is: 
C