国家: 以色列
语言: 英文
来源: Ministry of Health
HYDROMORPHONE HYDROCHLORIDE
RAFA LABORATORIES LTD
N02AA03
SOLUTION FOR INJECTION
HYDROMORPHONE HYDROCHLORIDE 20 MG / 2 ML
I.M, I.V, S.C
Required
RAFA LABORATORIES LTD, JERUSALEM
HYDROMORPHONE
HYDROMORPHONE
Relief of moderate to severe pain such as that due to surgery or cancer.
2012-04-30
1 Doctor Leaflet HIGHLY CONCENTRATED PALLADONE INJECTION 10 MG/ML (Preservative Free) Solution for injection IM, SC, IV Narcotic prescription required COMPOSITION Each 2 ml ampoule contains: Hydromorphone HCl 20 mg (10mg/ml). Palladone Injection also contains citric acid 2 mg/ml and tri-sodium citrate dihydrate 2.28 mg/ml Palladone Injection contains no preservatives. The solution is clear and colorless. ACTION Hydromorphone is a semisynthetic opioid agonist analgesic that acts primarily at the mu opiate receptor. Opiate receptors in the central nervous system mediate analgesic activity. Opioid agonists occupy the same receptors as endogenous opioid peptides (enkephalins or endorphins), and both may alter the central release of neurotransmitters from afferent nerves sensitive to noxious stimuli. Opioid antagonists block the opiate receptor, inhibit the pharmacological activity of the agonist and will precipitate withdrawal in dependent patients. Hydromorphone has similar pharmacological and pharmacokinetic properties to morphine to which it is chemically related. Hydromorphone is recognized by the World Health Organization as an alternative opioid to morphine for severe pain. This is important since one of the cornerstones of severe pain management is opioid rotation. Opioid rotation consists of switching a patient from one opioid to another in order to achieve adequate analgesia with few side effects. In particular, hydromorphone may have a better side effect profile than morphine in some individuals, producing less severe constipation and vomiting. In the post-operative setting as well, hydromorphone is a suitable alternative to morphine, especially in patients with a history of an unsatisfactory response to morphine e.g. excessive vomiting. There are several administration techniques for parenteral delivery of hydromorphone, including a single or double injection (e.g. post-operative), multiple intermittent bolus injections (e.g. in the cancer patient), or continuous infusion with or without bolus as-needed in 阅读完整的文件