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CORESTIN
CORESTIN
TM
(Rosuvastatin)
PRESENTATION
Corestinill 5 mg film-coated tablets. Each tablet contains
Rosuvastatin calcium INN corresponding
to 5mg rosuvastatin.
Corestinill 10 mg film-coated tablets. Each tablet contains
Rosuvastatin calcium INN corresponding
to 10mg rosuvastatin.
INDICATIONS
Corestin is indicated for patients with primary hypercholesterolaemia
(type lla including
heterozygous familial hypercholesterolaemia) or mixed dyslipidaemia
(type llb) as an adjunct to
diet when response to diet and exercise is inadequate.
Corestin reduces elevated LDL-cholesterol, total cholesterol,
triglycerides and ApoB, and increases
HDL-cholesterol.
Corestin is also indicated in patients with homozygous familial
hypercholesterolaemia, either alone
or as an adjunct to diet and other lipid lowering treatments (e.g. LDL
apheresis).
METHOD OF ADMINISTRATION
Before initiating treatment with Corestin, the patient should be
placed on a standard cholesterol-
lowering diet that should continue during treatment. The dose of
Corestin should be individualised
according to the goal of therapy and patient response, using current
consensus guidelines.
The usual start dose is Corestin 10 mg once daily and the majority of
patients are controlled at this
dose. A dose adjustment to 20 mg can be made after 4 weeks, if
necessary Corestin at a dose of 40
mg should only be used in patients with severe hypercholesterolaemia
(including those with familial
hypercholesterolaemia) who do not achieve their treatment goal on 20
mg. Corestin may be given at
any time of day, with or without food.
USE IN CHILDREN
Paediatric experience is limited to a small number of children (aged 8
years or above) with
homozygous familial hypercholesterolaemia. Use in children should be
super\/ised by specialists.
USE IN THE ELDERLY
No dose adjustment is necessary.
DOSAGE IN PATIENTS WITH RENAL INSUFFICIENCY
No dose adjustment is necessary in patients with mild to moderate
renal impairment. For patients
with severe renal impairment (CrCI <30 ml/min) the dose o
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