Ülke: Kanada
Dil: İngilizce
Kaynak: Health Canada
HEPARIN SODIUM
HOSPIRA HEALTHCARE ULC
B01AB01
HEPARIN
40UNIT
SOLUTION
HEPARIN SODIUM 40UNIT
INTRAVENOUS
500ML
Ethical
HEPARINS
Active ingredient group (AIG) number: 0104596010; AHFS:
CANCELLED POST MARKET
2018-11-22
PRESCRIBING INFORMATION HEPARIN SODIUM 20 000 UNITS/500 ML IN DEXTROSE 5% INJECTION HEPARIN SODIUM 25 000 UNITS/500 ML IN 5% DEXTROSE INJECTION Heparin Sodium in 5% Dextrose 20 000 or 25 000 USP Units in Flexible Plastic Container Anticoagulant Hospira Healthcare Corporation 17300 Trans-Canada Highway Kirkland, Quebec H9J 2M5 Date of Approval: May 09, 2017 Submission Control No: 203541 _______________________________________________________________________________ _ _Heparin Sodium in 20 000 Units/500 mL in Dextrose 5% Injection _ _Page 2 of 12 _ _Heparin Sodium in 25 000 Units/500 mL in 5% Dextrose Injection_ HEPARIN SODIUM 20 000 UNITS/500 ML IN DEXTROSE 5% INJECTION HEPARIN SODIUM 25 000 UNITS/500 ML IN 5% DEXTROSE INJECTION 20 000 or 25 000 USP Units in Flexible Plastic Container THERAPEUTIC CLASSIFICATION Anticoagulant CLINICAL PHARMACOLOGY Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both _in vitro _and _in vivo. _Heparin acts at multiple sites in the normal coagulation system. Small amounts of heparin in combination with antithrombin III (heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot in inhibiting the activation of the fibrin stabilizing factor. Bleeding time is usually unaffected by heparin. Clotting time is prolonged by full therapeutic doses of heparin; in most cases, it is not measurably affected by low doses of heparin. Peak plasma levels of heparin are achieved 2 to 4 hours following subcutaneous administration, although there are considerable individual variations. Log linear plots of heparin plasma concentrations, with time for a wide range of dose levels, are linear, which suggests the absence of zero order processes. The liver a Belgenin tamamını okuyun